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Simultaneous determination of ranitidine and metronidazole in pharmaceutical formulations at poly(chromotrope 2B) modified activated glassy carbon electrodes

A simple and sensitive electrochemical method for the simultaneous and quantitative detection of ranitidine (RT) and metronidazole (MT) was developed, based on a poly (chromotrope 2B) modified activated glassy carbon electrode (PCHAGCE). The PCHAGCE showed excellent electrocatalytic activity toward...

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Detalles Bibliográficos
Autores principales: Li, Xiaobo, Xu, Guangri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354867/
https://www.ncbi.nlm.nih.gov/pubmed/28911424
http://dx.doi.org/10.1016/j.jfda.2013.09.050
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author Li, Xiaobo
Xu, Guangri
author_facet Li, Xiaobo
Xu, Guangri
author_sort Li, Xiaobo
collection PubMed
description A simple and sensitive electrochemical method for the simultaneous and quantitative detection of ranitidine (RT) and metronidazole (MT) was developed, based on a poly (chromotrope 2B) modified activated glassy carbon electrode (PCHAGCE). The PCHAGCE showed excellent electrocatalytic activity toward the reduction of both RT and MT in 0.1 mol/L phosphate buffer solution (pH 6.0). The peak-to-peak separations for the simultaneous detection of RT and MT between the two reduction waves in cyclic voltammetry were increased significantly from ~0.1 V at activated GCE, to ~0.55 V at PCHAGCE. By differential pulse voltammetry techniques, the reduction peak currents of RT and MT were both linear over the range of 1.0 × 10(−5)–4.0 × 10(−4) mol/L. The detection limits (S/N = 3) were 5.4 × 10(−7) mol/L and 3.3 × 10(−7) mol/L for RT and MT, respectively. The modified electrode was successfully applied to the determination of RT and MT in pharmaceutical preparations and human serum as real samples with stable and reliable recovery data.
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spelling pubmed-93548672022-08-09 Simultaneous determination of ranitidine and metronidazole in pharmaceutical formulations at poly(chromotrope 2B) modified activated glassy carbon electrodes Li, Xiaobo Xu, Guangri J Food Drug Anal Original Article A simple and sensitive electrochemical method for the simultaneous and quantitative detection of ranitidine (RT) and metronidazole (MT) was developed, based on a poly (chromotrope 2B) modified activated glassy carbon electrode (PCHAGCE). The PCHAGCE showed excellent electrocatalytic activity toward the reduction of both RT and MT in 0.1 mol/L phosphate buffer solution (pH 6.0). The peak-to-peak separations for the simultaneous detection of RT and MT between the two reduction waves in cyclic voltammetry were increased significantly from ~0.1 V at activated GCE, to ~0.55 V at PCHAGCE. By differential pulse voltammetry techniques, the reduction peak currents of RT and MT were both linear over the range of 1.0 × 10(−5)–4.0 × 10(−4) mol/L. The detection limits (S/N = 3) were 5.4 × 10(−7) mol/L and 3.3 × 10(−7) mol/L for RT and MT, respectively. The modified electrode was successfully applied to the determination of RT and MT in pharmaceutical preparations and human serum as real samples with stable and reliable recovery data. Taiwan Food and Drug Administration 2013-12-08 /pmc/articles/PMC9354867/ /pubmed/28911424 http://dx.doi.org/10.1016/j.jfda.2013.09.050 Text en © 2014 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Article
Li, Xiaobo
Xu, Guangri
Simultaneous determination of ranitidine and metronidazole in pharmaceutical formulations at poly(chromotrope 2B) modified activated glassy carbon electrodes
title Simultaneous determination of ranitidine and metronidazole in pharmaceutical formulations at poly(chromotrope 2B) modified activated glassy carbon electrodes
title_full Simultaneous determination of ranitidine and metronidazole in pharmaceutical formulations at poly(chromotrope 2B) modified activated glassy carbon electrodes
title_fullStr Simultaneous determination of ranitidine and metronidazole in pharmaceutical formulations at poly(chromotrope 2B) modified activated glassy carbon electrodes
title_full_unstemmed Simultaneous determination of ranitidine and metronidazole in pharmaceutical formulations at poly(chromotrope 2B) modified activated glassy carbon electrodes
title_short Simultaneous determination of ranitidine and metronidazole in pharmaceutical formulations at poly(chromotrope 2B) modified activated glassy carbon electrodes
title_sort simultaneous determination of ranitidine and metronidazole in pharmaceutical formulations at poly(chromotrope 2b) modified activated glassy carbon electrodes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354867/
https://www.ncbi.nlm.nih.gov/pubmed/28911424
http://dx.doi.org/10.1016/j.jfda.2013.09.050
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