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The Hypoglycemic Effect of JinQi Jiangtang Tablets Is Partially Dependent on the Palmatine-Induced Activation of the Fibroblast Growth Factor Receptor 1 Signaling Pathway

JinQi Jiangtang tablet (JQJTT) is a Chinese patent medicine that has been shown to be beneficial for patients with diabetes both preclinically and clinically; however, the molecular mechanism underlying the effects of JQJTT remains unclear. In this study, surface plasmon resonance fishing was employ...

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Autores principales: Li, Siming, Li, Xiaoling, Wang, HeMeng, Jia, Xinhang, Mao, Haoyang, Dong, Fangxin, Zhao, Tingting, Gao, Yuan, Zhang, Chen, Bai, Ruisong, Liu, Ruihao, Yan, Lijun, Ji, Yubin, Zhang, Na, Wang, Wenfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354937/
https://www.ncbi.nlm.nih.gov/pubmed/35935824
http://dx.doi.org/10.3389/fphar.2022.895724
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author Li, Siming
Li, Xiaoling
Wang, HeMeng
Jia, Xinhang
Mao, Haoyang
Dong, Fangxin
Zhao, Tingting
Gao, Yuan
Zhang, Chen
Bai, Ruisong
Liu, Ruihao
Yan, Lijun
Ji, Yubin
Zhang, Na
Wang, Wenfei
author_facet Li, Siming
Li, Xiaoling
Wang, HeMeng
Jia, Xinhang
Mao, Haoyang
Dong, Fangxin
Zhao, Tingting
Gao, Yuan
Zhang, Chen
Bai, Ruisong
Liu, Ruihao
Yan, Lijun
Ji, Yubin
Zhang, Na
Wang, Wenfei
author_sort Li, Siming
collection PubMed
description JinQi Jiangtang tablet (JQJTT) is a Chinese patent medicine that has been shown to be beneficial for patients with diabetes both preclinically and clinically; however, the molecular mechanism underlying the effects of JQJTT remains unclear. In this study, surface plasmon resonance fishing was employed to identify JQJTT constituent molecules that can specifically bind to fibroblast growth factor receptor 1 (FGFR1), leading to the retrieval of palmatine (PAL), a key active ingredient of JQJTT. In vivo and in vitro experiments demonstrated that PAL can significantly stimulate FGFR1 phosphorylation and upregulate glucose transporter type 1 (GLUT-1) expression, thereby facilitating glucose uptake in insulin resistance (IR) HepG2 cells as well as alleviating hyperglycemia in diabetic mice. Our results revealed that PAL functions as an FGFR1 activator and that the hypoglycemic effect of JQJTT is partially dependent on the PAL-induced activation of the FGFR1 pathway. In addition, this study contributed to the understanding the pharmacodynamic basis and mechanism of action of JQJTT and provided a novel concept for future research on PAL.
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spelling pubmed-93549372022-08-06 The Hypoglycemic Effect of JinQi Jiangtang Tablets Is Partially Dependent on the Palmatine-Induced Activation of the Fibroblast Growth Factor Receptor 1 Signaling Pathway Li, Siming Li, Xiaoling Wang, HeMeng Jia, Xinhang Mao, Haoyang Dong, Fangxin Zhao, Tingting Gao, Yuan Zhang, Chen Bai, Ruisong Liu, Ruihao Yan, Lijun Ji, Yubin Zhang, Na Wang, Wenfei Front Pharmacol Pharmacology JinQi Jiangtang tablet (JQJTT) is a Chinese patent medicine that has been shown to be beneficial for patients with diabetes both preclinically and clinically; however, the molecular mechanism underlying the effects of JQJTT remains unclear. In this study, surface plasmon resonance fishing was employed to identify JQJTT constituent molecules that can specifically bind to fibroblast growth factor receptor 1 (FGFR1), leading to the retrieval of palmatine (PAL), a key active ingredient of JQJTT. In vivo and in vitro experiments demonstrated that PAL can significantly stimulate FGFR1 phosphorylation and upregulate glucose transporter type 1 (GLUT-1) expression, thereby facilitating glucose uptake in insulin resistance (IR) HepG2 cells as well as alleviating hyperglycemia in diabetic mice. Our results revealed that PAL functions as an FGFR1 activator and that the hypoglycemic effect of JQJTT is partially dependent on the PAL-induced activation of the FGFR1 pathway. In addition, this study contributed to the understanding the pharmacodynamic basis and mechanism of action of JQJTT and provided a novel concept for future research on PAL. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9354937/ /pubmed/35935824 http://dx.doi.org/10.3389/fphar.2022.895724 Text en Copyright © 2022 Li, Li, Wang, Jia, Mao, Dong, Zhao, Gao, Zhang, Bai, Liu, Yan, Ji, Zhang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Siming
Li, Xiaoling
Wang, HeMeng
Jia, Xinhang
Mao, Haoyang
Dong, Fangxin
Zhao, Tingting
Gao, Yuan
Zhang, Chen
Bai, Ruisong
Liu, Ruihao
Yan, Lijun
Ji, Yubin
Zhang, Na
Wang, Wenfei
The Hypoglycemic Effect of JinQi Jiangtang Tablets Is Partially Dependent on the Palmatine-Induced Activation of the Fibroblast Growth Factor Receptor 1 Signaling Pathway
title The Hypoglycemic Effect of JinQi Jiangtang Tablets Is Partially Dependent on the Palmatine-Induced Activation of the Fibroblast Growth Factor Receptor 1 Signaling Pathway
title_full The Hypoglycemic Effect of JinQi Jiangtang Tablets Is Partially Dependent on the Palmatine-Induced Activation of the Fibroblast Growth Factor Receptor 1 Signaling Pathway
title_fullStr The Hypoglycemic Effect of JinQi Jiangtang Tablets Is Partially Dependent on the Palmatine-Induced Activation of the Fibroblast Growth Factor Receptor 1 Signaling Pathway
title_full_unstemmed The Hypoglycemic Effect of JinQi Jiangtang Tablets Is Partially Dependent on the Palmatine-Induced Activation of the Fibroblast Growth Factor Receptor 1 Signaling Pathway
title_short The Hypoglycemic Effect of JinQi Jiangtang Tablets Is Partially Dependent on the Palmatine-Induced Activation of the Fibroblast Growth Factor Receptor 1 Signaling Pathway
title_sort hypoglycemic effect of jinqi jiangtang tablets is partially dependent on the palmatine-induced activation of the fibroblast growth factor receptor 1 signaling pathway
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354937/
https://www.ncbi.nlm.nih.gov/pubmed/35935824
http://dx.doi.org/10.3389/fphar.2022.895724
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