Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis

As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate. As high-throughput sequencing and antibody technologies advanced by...

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Detalles Bibliográficos
Autores principales: Chen, Hui-Ming, Li, Hang, Lin, Meng-Xian, Fan, Wei-Jie, Zhang, Yi, Lin, Yan-Ting, Wu, Shu-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354963/
https://www.ncbi.nlm.nih.gov/pubmed/35937999
http://dx.doi.org/10.3389/fgene.2022.952667
Descripción
Sumario:As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate. As high-throughput sequencing and antibody technologies advanced by leaps and bounds, the association of RNA modifications with multiple human diseases sparked research enthusiasm; in addition, aberrant RNA modification leads to tumor angiogenesis by regulating angiogenesis-related factors. This review collected recent cutting-edge studies focused on RNA modifications (N(6)-methyladenosine (m(6)A), N(5)-methylcytosine (m(5)C), N(7)-methylguanosine (m(7)G), N(1)-methyladenosine (m(1)A), and pseudopuridine (Ψ)), and their related regulators in tumor angiogenesis to emphasize the role and impact of RNA modifications.

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