Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis

As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate. As high-throughput sequencing and antibody technologies advanced by...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Hui-Ming, Li, Hang, Lin, Meng-Xian, Fan, Wei-Jie, Zhang, Yi, Lin, Yan-Ting, Wu, Shu-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354963/
https://www.ncbi.nlm.nih.gov/pubmed/35937999
http://dx.doi.org/10.3389/fgene.2022.952667
_version_ 1784763187509329920
author Chen, Hui-Ming
Li, Hang
Lin, Meng-Xian
Fan, Wei-Jie
Zhang, Yi
Lin, Yan-Ting
Wu, Shu-Xiang
author_facet Chen, Hui-Ming
Li, Hang
Lin, Meng-Xian
Fan, Wei-Jie
Zhang, Yi
Lin, Yan-Ting
Wu, Shu-Xiang
author_sort Chen, Hui-Ming
collection PubMed
description As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate. As high-throughput sequencing and antibody technologies advanced by leaps and bounds, the association of RNA modifications with multiple human diseases sparked research enthusiasm; in addition, aberrant RNA modification leads to tumor angiogenesis by regulating angiogenesis-related factors. This review collected recent cutting-edge studies focused on RNA modifications (N(6)-methyladenosine (m(6)A), N(5)-methylcytosine (m(5)C), N(7)-methylguanosine (m(7)G), N(1)-methyladenosine (m(1)A), and pseudopuridine (Ψ)), and their related regulators in tumor angiogenesis to emphasize the role and impact of RNA modifications.
format Online
Article
Text
id pubmed-9354963
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93549632022-08-06 Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis Chen, Hui-Ming Li, Hang Lin, Meng-Xian Fan, Wei-Jie Zhang, Yi Lin, Yan-Ting Wu, Shu-Xiang Front Genet Genetics As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate. As high-throughput sequencing and antibody technologies advanced by leaps and bounds, the association of RNA modifications with multiple human diseases sparked research enthusiasm; in addition, aberrant RNA modification leads to tumor angiogenesis by regulating angiogenesis-related factors. This review collected recent cutting-edge studies focused on RNA modifications (N(6)-methyladenosine (m(6)A), N(5)-methylcytosine (m(5)C), N(7)-methylguanosine (m(7)G), N(1)-methyladenosine (m(1)A), and pseudopuridine (Ψ)), and their related regulators in tumor angiogenesis to emphasize the role and impact of RNA modifications. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9354963/ /pubmed/35937999 http://dx.doi.org/10.3389/fgene.2022.952667 Text en Copyright © 2022 Chen, Li, Lin, Fan, Zhang, Lin and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Chen, Hui-Ming
Li, Hang
Lin, Meng-Xian
Fan, Wei-Jie
Zhang, Yi
Lin, Yan-Ting
Wu, Shu-Xiang
Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis
title Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis
title_full Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis
title_fullStr Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis
title_full_unstemmed Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis
title_short Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis
title_sort research progress for rna modifications in physiological and pathological angiogenesis
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354963/
https://www.ncbi.nlm.nih.gov/pubmed/35937999
http://dx.doi.org/10.3389/fgene.2022.952667
work_keys_str_mv AT chenhuiming researchprogressforrnamodificationsinphysiologicalandpathologicalangiogenesis
AT lihang researchprogressforrnamodificationsinphysiologicalandpathologicalangiogenesis
AT linmengxian researchprogressforrnamodificationsinphysiologicalandpathologicalangiogenesis
AT fanweijie researchprogressforrnamodificationsinphysiologicalandpathologicalangiogenesis
AT zhangyi researchprogressforrnamodificationsinphysiologicalandpathologicalangiogenesis
AT linyanting researchprogressforrnamodificationsinphysiologicalandpathologicalangiogenesis
AT wushuxiang researchprogressforrnamodificationsinphysiologicalandpathologicalangiogenesis

Ejemplares similares