Cargando…

Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior

Autism spectrum disorders (ASD) is a group of generalized neurodevelopmental disorders. Its main clinical features are social communication disorder and repetitive stereotyped behavioral interest. The abnormal structure and function of brain network is the basis of social dysfunction and stereotyped...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Feng, Zhang, Hao, Wang, Peng, Cui, Wenjie, Xu, Kaiyong, Chen, Dan, Hu, Minghui, Li, Zifa, Geng, Xiwen, Wei, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354980/
https://www.ncbi.nlm.nih.gov/pubmed/35937893
http://dx.doi.org/10.3389/fnins.2022.919890
_version_ 1784763191173054464
author Zhao, Feng
Zhang, Hao
Wang, Peng
Cui, Wenjie
Xu, Kaiyong
Chen, Dan
Hu, Minghui
Li, Zifa
Geng, Xiwen
Wei, Sheng
author_facet Zhao, Feng
Zhang, Hao
Wang, Peng
Cui, Wenjie
Xu, Kaiyong
Chen, Dan
Hu, Minghui
Li, Zifa
Geng, Xiwen
Wei, Sheng
author_sort Zhao, Feng
collection PubMed
description Autism spectrum disorders (ASD) is a group of generalized neurodevelopmental disorders. Its main clinical features are social communication disorder and repetitive stereotyped behavioral interest. The abnormal structure and function of brain network is the basis of social dysfunction and stereotyped performance in patients with autism spectrum disorder. The number of patients diagnosed with ASD has increased year by year, but there is a lack of effective intervention and treatment. Oxytocin has been revealed to effectively improve social cognitive function and significantly improve the social information processing ability, empathy ability and social communication ability of ASD patients. The change of serotonin level also been reported affecting the development of brain and causes ASD-like behavioral abnormalities, such as anxiety, depression like behavior, stereotyped behavior. Present review will focus on the research progress of serotonin and oxytocin in the pathogenesis, brain circuit changes and treatment of autism. Revealing the regulatory effect and neural mechanism of serotonin and oxytocin on patients with ASD is not only conducive to a deeper comprehension of the pathogenesis of ASD, but also has vital clinical significance.
format Online
Article
Text
id pubmed-9354980
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93549802022-08-06 Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior Zhao, Feng Zhang, Hao Wang, Peng Cui, Wenjie Xu, Kaiyong Chen, Dan Hu, Minghui Li, Zifa Geng, Xiwen Wei, Sheng Front Neurosci Neuroscience Autism spectrum disorders (ASD) is a group of generalized neurodevelopmental disorders. Its main clinical features are social communication disorder and repetitive stereotyped behavioral interest. The abnormal structure and function of brain network is the basis of social dysfunction and stereotyped performance in patients with autism spectrum disorder. The number of patients diagnosed with ASD has increased year by year, but there is a lack of effective intervention and treatment. Oxytocin has been revealed to effectively improve social cognitive function and significantly improve the social information processing ability, empathy ability and social communication ability of ASD patients. The change of serotonin level also been reported affecting the development of brain and causes ASD-like behavioral abnormalities, such as anxiety, depression like behavior, stereotyped behavior. Present review will focus on the research progress of serotonin and oxytocin in the pathogenesis, brain circuit changes and treatment of autism. Revealing the regulatory effect and neural mechanism of serotonin and oxytocin on patients with ASD is not only conducive to a deeper comprehension of the pathogenesis of ASD, but also has vital clinical significance. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9354980/ /pubmed/35937893 http://dx.doi.org/10.3389/fnins.2022.919890 Text en Copyright © 2022 Zhao, Zhang, Wang, Cui, Xu, Chen, Hu, Li, Geng and Wei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhao, Feng
Zhang, Hao
Wang, Peng
Cui, Wenjie
Xu, Kaiyong
Chen, Dan
Hu, Minghui
Li, Zifa
Geng, Xiwen
Wei, Sheng
Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior
title Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior
title_full Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior
title_fullStr Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior
title_full_unstemmed Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior
title_short Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior
title_sort oxytocin and serotonin in the modulation of neural function: neurobiological underpinnings of autism-related behavior
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354980/
https://www.ncbi.nlm.nih.gov/pubmed/35937893
http://dx.doi.org/10.3389/fnins.2022.919890
work_keys_str_mv AT zhaofeng oxytocinandserotonininthemodulationofneuralfunctionneurobiologicalunderpinningsofautismrelatedbehavior
AT zhanghao oxytocinandserotonininthemodulationofneuralfunctionneurobiologicalunderpinningsofautismrelatedbehavior
AT wangpeng oxytocinandserotonininthemodulationofneuralfunctionneurobiologicalunderpinningsofautismrelatedbehavior
AT cuiwenjie oxytocinandserotonininthemodulationofneuralfunctionneurobiologicalunderpinningsofautismrelatedbehavior
AT xukaiyong oxytocinandserotonininthemodulationofneuralfunctionneurobiologicalunderpinningsofautismrelatedbehavior
AT chendan oxytocinandserotonininthemodulationofneuralfunctionneurobiologicalunderpinningsofautismrelatedbehavior
AT huminghui oxytocinandserotonininthemodulationofneuralfunctionneurobiologicalunderpinningsofautismrelatedbehavior
AT lizifa oxytocinandserotonininthemodulationofneuralfunctionneurobiologicalunderpinningsofautismrelatedbehavior
AT gengxiwen oxytocinandserotonininthemodulationofneuralfunctionneurobiologicalunderpinningsofautismrelatedbehavior
AT weisheng oxytocinandserotonininthemodulationofneuralfunctionneurobiologicalunderpinningsofautismrelatedbehavior