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Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior
Autism spectrum disorders (ASD) is a group of generalized neurodevelopmental disorders. Its main clinical features are social communication disorder and repetitive stereotyped behavioral interest. The abnormal structure and function of brain network is the basis of social dysfunction and stereotyped...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354980/ https://www.ncbi.nlm.nih.gov/pubmed/35937893 http://dx.doi.org/10.3389/fnins.2022.919890 |
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author | Zhao, Feng Zhang, Hao Wang, Peng Cui, Wenjie Xu, Kaiyong Chen, Dan Hu, Minghui Li, Zifa Geng, Xiwen Wei, Sheng |
author_facet | Zhao, Feng Zhang, Hao Wang, Peng Cui, Wenjie Xu, Kaiyong Chen, Dan Hu, Minghui Li, Zifa Geng, Xiwen Wei, Sheng |
author_sort | Zhao, Feng |
collection | PubMed |
description | Autism spectrum disorders (ASD) is a group of generalized neurodevelopmental disorders. Its main clinical features are social communication disorder and repetitive stereotyped behavioral interest. The abnormal structure and function of brain network is the basis of social dysfunction and stereotyped performance in patients with autism spectrum disorder. The number of patients diagnosed with ASD has increased year by year, but there is a lack of effective intervention and treatment. Oxytocin has been revealed to effectively improve social cognitive function and significantly improve the social information processing ability, empathy ability and social communication ability of ASD patients. The change of serotonin level also been reported affecting the development of brain and causes ASD-like behavioral abnormalities, such as anxiety, depression like behavior, stereotyped behavior. Present review will focus on the research progress of serotonin and oxytocin in the pathogenesis, brain circuit changes and treatment of autism. Revealing the regulatory effect and neural mechanism of serotonin and oxytocin on patients with ASD is not only conducive to a deeper comprehension of the pathogenesis of ASD, but also has vital clinical significance. |
format | Online Article Text |
id | pubmed-9354980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93549802022-08-06 Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior Zhao, Feng Zhang, Hao Wang, Peng Cui, Wenjie Xu, Kaiyong Chen, Dan Hu, Minghui Li, Zifa Geng, Xiwen Wei, Sheng Front Neurosci Neuroscience Autism spectrum disorders (ASD) is a group of generalized neurodevelopmental disorders. Its main clinical features are social communication disorder and repetitive stereotyped behavioral interest. The abnormal structure and function of brain network is the basis of social dysfunction and stereotyped performance in patients with autism spectrum disorder. The number of patients diagnosed with ASD has increased year by year, but there is a lack of effective intervention and treatment. Oxytocin has been revealed to effectively improve social cognitive function and significantly improve the social information processing ability, empathy ability and social communication ability of ASD patients. The change of serotonin level also been reported affecting the development of brain and causes ASD-like behavioral abnormalities, such as anxiety, depression like behavior, stereotyped behavior. Present review will focus on the research progress of serotonin and oxytocin in the pathogenesis, brain circuit changes and treatment of autism. Revealing the regulatory effect and neural mechanism of serotonin and oxytocin on patients with ASD is not only conducive to a deeper comprehension of the pathogenesis of ASD, but also has vital clinical significance. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9354980/ /pubmed/35937893 http://dx.doi.org/10.3389/fnins.2022.919890 Text en Copyright © 2022 Zhao, Zhang, Wang, Cui, Xu, Chen, Hu, Li, Geng and Wei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhao, Feng Zhang, Hao Wang, Peng Cui, Wenjie Xu, Kaiyong Chen, Dan Hu, Minghui Li, Zifa Geng, Xiwen Wei, Sheng Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior |
title | Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior |
title_full | Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior |
title_fullStr | Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior |
title_full_unstemmed | Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior |
title_short | Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior |
title_sort | oxytocin and serotonin in the modulation of neural function: neurobiological underpinnings of autism-related behavior |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354980/ https://www.ncbi.nlm.nih.gov/pubmed/35937893 http://dx.doi.org/10.3389/fnins.2022.919890 |
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