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Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial
Virgin Coconut Oil (VCO) with potential fatty acid content has a strong antibacterial effect for drug and cosmetics. VCO was hydrolyzed as hydrolyzed VCO (HVCO) to increase its activity. This study aims to optimize VCO and HVCO microspheres. Examination was included fatty acid content, density, and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355055/ https://www.ncbi.nlm.nih.gov/pubmed/35935685 http://dx.doi.org/10.4103/japtr.japtr_99_22 |
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author | Hariyadi, Dewi Melani Fitri, Aldesra Sudarma, Sisunandar Purwanti, Tutiek Erawati, Tristiana |
author_facet | Hariyadi, Dewi Melani Fitri, Aldesra Sudarma, Sisunandar Purwanti, Tutiek Erawati, Tristiana |
author_sort | Hariyadi, Dewi Melani |
collection | PubMed |
description | Virgin Coconut Oil (VCO) with potential fatty acid content has a strong antibacterial effect for drug and cosmetics. VCO was hydrolyzed as hydrolyzed VCO (HVCO) to increase its activity. This study aims to optimize VCO and HVCO microspheres. Examination was included fatty acid content, density, and organoleptic. VCO and HVCO microspheres were characterized by yield, moisture content (MC), morphology, and size. Fatty acid content was done through gas chromatography mass spectrometry whereas for microspheres, effect of alginate concentration (1%–2%), and addition of poly ethylene glycol (PEG) were studied. VCO and HVCO microspheres formulas showed that an increase in polymer concentration, increasing yield, and improving MC. The most optimal 2% alginate with the addition of PEG increased yield up to 59% and reduced size. F4 microspheres resulted the highest yield, low MC, and high fatty acids. Morphology was spherical and smooth with small size. Optimization of HVCO microspheres showed its potential which recommend for antibacterial and antifungal activity. |
format | Online Article Text |
id | pubmed-9355055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-93550552022-08-06 Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial Hariyadi, Dewi Melani Fitri, Aldesra Sudarma, Sisunandar Purwanti, Tutiek Erawati, Tristiana J Adv Pharm Technol Res Original Article Virgin Coconut Oil (VCO) with potential fatty acid content has a strong antibacterial effect for drug and cosmetics. VCO was hydrolyzed as hydrolyzed VCO (HVCO) to increase its activity. This study aims to optimize VCO and HVCO microspheres. Examination was included fatty acid content, density, and organoleptic. VCO and HVCO microspheres were characterized by yield, moisture content (MC), morphology, and size. Fatty acid content was done through gas chromatography mass spectrometry whereas for microspheres, effect of alginate concentration (1%–2%), and addition of poly ethylene glycol (PEG) were studied. VCO and HVCO microspheres formulas showed that an increase in polymer concentration, increasing yield, and improving MC. The most optimal 2% alginate with the addition of PEG increased yield up to 59% and reduced size. F4 microspheres resulted the highest yield, low MC, and high fatty acids. Morphology was spherical and smooth with small size. Optimization of HVCO microspheres showed its potential which recommend for antibacterial and antifungal activity. Wolters Kluwer - Medknow 2022 2022-07-05 /pmc/articles/PMC9355055/ /pubmed/35935685 http://dx.doi.org/10.4103/japtr.japtr_99_22 Text en Copyright: © 2022 Journal of Advanced Pharmaceutical Technology & Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Hariyadi, Dewi Melani Fitri, Aldesra Sudarma, Sisunandar Purwanti, Tutiek Erawati, Tristiana Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
title | Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
title_full | Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
title_fullStr | Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
title_full_unstemmed | Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
title_short | Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
title_sort | optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355055/ https://www.ncbi.nlm.nih.gov/pubmed/35935685 http://dx.doi.org/10.4103/japtr.japtr_99_22 |
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