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Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial

Virgin Coconut Oil (VCO) with potential fatty acid content has a strong antibacterial effect for drug and cosmetics. VCO was hydrolyzed as hydrolyzed VCO (HVCO) to increase its activity. This study aims to optimize VCO and HVCO microspheres. Examination was included fatty acid content, density, and...

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Autores principales: Hariyadi, Dewi Melani, Fitri, Aldesra, Sudarma, Sisunandar, Purwanti, Tutiek, Erawati, Tristiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355055/
https://www.ncbi.nlm.nih.gov/pubmed/35935685
http://dx.doi.org/10.4103/japtr.japtr_99_22
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author Hariyadi, Dewi Melani
Fitri, Aldesra
Sudarma, Sisunandar
Purwanti, Tutiek
Erawati, Tristiana
author_facet Hariyadi, Dewi Melani
Fitri, Aldesra
Sudarma, Sisunandar
Purwanti, Tutiek
Erawati, Tristiana
author_sort Hariyadi, Dewi Melani
collection PubMed
description Virgin Coconut Oil (VCO) with potential fatty acid content has a strong antibacterial effect for drug and cosmetics. VCO was hydrolyzed as hydrolyzed VCO (HVCO) to increase its activity. This study aims to optimize VCO and HVCO microspheres. Examination was included fatty acid content, density, and organoleptic. VCO and HVCO microspheres were characterized by yield, moisture content (MC), morphology, and size. Fatty acid content was done through gas chromatography mass spectrometry whereas for microspheres, effect of alginate concentration (1%–2%), and addition of poly ethylene glycol (PEG) were studied. VCO and HVCO microspheres formulas showed that an increase in polymer concentration, increasing yield, and improving MC. The most optimal 2% alginate with the addition of PEG increased yield up to 59% and reduced size. F4 microspheres resulted the highest yield, low MC, and high fatty acids. Morphology was spherical and smooth with small size. Optimization of HVCO microspheres showed its potential which recommend for antibacterial and antifungal activity.
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spelling pubmed-93550552022-08-06 Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial Hariyadi, Dewi Melani Fitri, Aldesra Sudarma, Sisunandar Purwanti, Tutiek Erawati, Tristiana J Adv Pharm Technol Res Original Article Virgin Coconut Oil (VCO) with potential fatty acid content has a strong antibacterial effect for drug and cosmetics. VCO was hydrolyzed as hydrolyzed VCO (HVCO) to increase its activity. This study aims to optimize VCO and HVCO microspheres. Examination was included fatty acid content, density, and organoleptic. VCO and HVCO microspheres were characterized by yield, moisture content (MC), morphology, and size. Fatty acid content was done through gas chromatography mass spectrometry whereas for microspheres, effect of alginate concentration (1%–2%), and addition of poly ethylene glycol (PEG) were studied. VCO and HVCO microspheres formulas showed that an increase in polymer concentration, increasing yield, and improving MC. The most optimal 2% alginate with the addition of PEG increased yield up to 59% and reduced size. F4 microspheres resulted the highest yield, low MC, and high fatty acids. Morphology was spherical and smooth with small size. Optimization of HVCO microspheres showed its potential which recommend for antibacterial and antifungal activity. Wolters Kluwer - Medknow 2022 2022-07-05 /pmc/articles/PMC9355055/ /pubmed/35935685 http://dx.doi.org/10.4103/japtr.japtr_99_22 Text en Copyright: © 2022 Journal of Advanced Pharmaceutical Technology & Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Hariyadi, Dewi Melani
Fitri, Aldesra
Sudarma, Sisunandar
Purwanti, Tutiek
Erawati, Tristiana
Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial
title Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial
title_full Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial
title_fullStr Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial
title_full_unstemmed Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial
title_short Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial
title_sort optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355055/
https://www.ncbi.nlm.nih.gov/pubmed/35935685
http://dx.doi.org/10.4103/japtr.japtr_99_22
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