The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases

E3 ubiquitin ligases determine the substrate specificity and catalyze the ubiquitination of lysine residues. HUWE1 is a catalytic HECT domain-containing giant E3 ligase that contains a substrate-binding ring structure, and mediates the ubiquitination of more than 40 diverse substrates. HUWE1 serves...

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Detalles Bibliográficos
Autores principales: Qi, Lu, Xu, Xiaoqing, Qi, Xiaopeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355080/
https://www.ncbi.nlm.nih.gov/pubmed/35937685
http://dx.doi.org/10.3389/fcimb.2022.905906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355080/
https://www.ncbi.nlm.nih.gov/pubmed/35937685
http://dx.doi.org/10.3389/fcimb.2022.905906

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