FXR deficiency in hepatocytes disrupts the bile acid homeostasis and inhibits autophagy to promote liver injury in Schistosoma japonicum-infected mice

BACKGROUND: Schistosomiasis, with 250 million people affected, is characterized by its serious hepatic inflammatory response and fibrosis formation, which could lead to dangerous complications, such as portal hypertension, splenomegaly and even ascites. But until now, the pathogenesis of schistosomi...

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Detalles Bibliográficos
Autores principales: Zhang, Beibei, Li, Jing, Zong, Xianlong, Wang, Jianling, Xin, Lianlian, Song, Haiyao, Zhang, Wenxue, Koda, Stephane, Hua, Hui, Zhang, Bo, Yu, Qian, Zheng, Kui-Yang, Yan, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355238/
https://www.ncbi.nlm.nih.gov/pubmed/35930537
http://dx.doi.org/10.1371/journal.pntd.0010651

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