Pro-angiogenic New Chloro-Azaphilone Derivatives From the Hadal Trench-Derived Fungus Chaetomium globosum YP-106

Five new chloro-azaphilones, chaetofanixins A–E (1–5), and five known analogs (6–10) were isolated and identified from the hadal trench-derived fungus Chaetomium globosum YP-106. The structure of chaetofanixin E (5) is unique and interesting, bearing a highly rigid 6/6/5/3/5 penta-cyclic ring system...

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Autores principales: Fan, Yaqin, Jiang, Chunjiao, Zhang, Yan, Ma, Zhiheng, Li, Peihai, Guo, Lizhong, Feng, Ting, Zhou, Liman, Xu, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355395/
https://www.ncbi.nlm.nih.gov/pubmed/35935205
http://dx.doi.org/10.3389/fmicb.2022.943452
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author Fan, Yaqin
Jiang, Chunjiao
Zhang, Yan
Ma, Zhiheng
Li, Peihai
Guo, Lizhong
Feng, Ting
Zhou, Liman
Xu, Lili
author_facet Fan, Yaqin
Jiang, Chunjiao
Zhang, Yan
Ma, Zhiheng
Li, Peihai
Guo, Lizhong
Feng, Ting
Zhou, Liman
Xu, Lili
author_sort Fan, Yaqin
collection PubMed
description Five new chloro-azaphilones, chaetofanixins A–E (1–5), and five known analogs (6–10) were isolated and identified from the hadal trench-derived fungus Chaetomium globosum YP-106. The structure of chaetofanixin E (5) is unique and interesting, bearing a highly rigid 6/6/5/3/5 penta-cyclic ring system, which is first encountered in natural products. The structures of these compounds, including absolute configurations, were determined based on the spectroscopic analysis, electronic circular dichroism (ECD) calculations, and analysis of biogenetic origins. Compounds 1–7 significantly promoted angiogenesis in a dose-dependent manner, and thus, these compounds might be used as promising molecules for the development of natural cardiovascular disease agents.
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spelling pubmed-93553952022-08-06 Pro-angiogenic New Chloro-Azaphilone Derivatives From the Hadal Trench-Derived Fungus Chaetomium globosum YP-106 Fan, Yaqin Jiang, Chunjiao Zhang, Yan Ma, Zhiheng Li, Peihai Guo, Lizhong Feng, Ting Zhou, Liman Xu, Lili Front Microbiol Microbiology Five new chloro-azaphilones, chaetofanixins A–E (1–5), and five known analogs (6–10) were isolated and identified from the hadal trench-derived fungus Chaetomium globosum YP-106. The structure of chaetofanixin E (5) is unique and interesting, bearing a highly rigid 6/6/5/3/5 penta-cyclic ring system, which is first encountered in natural products. The structures of these compounds, including absolute configurations, were determined based on the spectroscopic analysis, electronic circular dichroism (ECD) calculations, and analysis of biogenetic origins. Compounds 1–7 significantly promoted angiogenesis in a dose-dependent manner, and thus, these compounds might be used as promising molecules for the development of natural cardiovascular disease agents. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9355395/ /pubmed/35935205 http://dx.doi.org/10.3389/fmicb.2022.943452 Text en Copyright © 2022 Fan, Jiang, Zhang, Ma, Li, Guo, Feng, Zhou and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Fan, Yaqin
Jiang, Chunjiao
Zhang, Yan
Ma, Zhiheng
Li, Peihai
Guo, Lizhong
Feng, Ting
Zhou, Liman
Xu, Lili
Pro-angiogenic New Chloro-Azaphilone Derivatives From the Hadal Trench-Derived Fungus Chaetomium globosum YP-106
title Pro-angiogenic New Chloro-Azaphilone Derivatives From the Hadal Trench-Derived Fungus Chaetomium globosum YP-106
title_full Pro-angiogenic New Chloro-Azaphilone Derivatives From the Hadal Trench-Derived Fungus Chaetomium globosum YP-106
title_fullStr Pro-angiogenic New Chloro-Azaphilone Derivatives From the Hadal Trench-Derived Fungus Chaetomium globosum YP-106
title_full_unstemmed Pro-angiogenic New Chloro-Azaphilone Derivatives From the Hadal Trench-Derived Fungus Chaetomium globosum YP-106
title_short Pro-angiogenic New Chloro-Azaphilone Derivatives From the Hadal Trench-Derived Fungus Chaetomium globosum YP-106
title_sort pro-angiogenic new chloro-azaphilone derivatives from the hadal trench-derived fungus chaetomium globosum yp-106
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355395/
https://www.ncbi.nlm.nih.gov/pubmed/35935205
http://dx.doi.org/10.3389/fmicb.2022.943452
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