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Targeting 17β-estradiol biosynthesis in neural stem cells improves stroke outcome

Dax-1 (dosage-sensitive sex reversal adrenal hypoplasia congenital region on X-chromosome gene 1) blocks 17β-estradiol biosynthesis and its knockdown would be expected to increase 17β-estradiol production. We hypothesized that knockdown of Dax-1 in a conditionally immortalized neural stem cell (NSC)...

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Detalles Bibliográficos
Autores principales:	Patkar, Shalmali, Uwanogho, Dafe, Modo, Michel, Tate, Rothwelle J., Plevin, Robin, Carswell, Hilary V. O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355602/ https://www.ncbi.nlm.nih.gov/pubmed/35936502 http://dx.doi.org/10.3389/fncel.2022.917181

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