GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility

Coronavirus disease 19 (COVID-19) is a persistent global pandemic with a very heterogeneous disease presentation ranging from a mild disease to dismal prognosis. Early detection of sensitivity and severity of COVID-19 is essential for the development of new treatments. In the present study, we measu...

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Autores principales: Torrens-Mas, Margalida, Perelló-Reus, Catalina M., Trias-Ferrer, Neus, Ibargüen-González, Lesly, Crespí, Catalina, Galmes-Panades, Aina Maria, Navas-Enamorado, Cayetano, Sanchez-Polo, Andres, Piérola-Lopetegui, Javier, Masmiquel, Luis, Crespi, Lorenzo Socias, Barcelo, Carles, Gonzalez-Freire, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355674/
https://www.ncbi.nlm.nih.gov/pubmed/35937703
http://dx.doi.org/10.3389/fcimb.2022.942951
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author Torrens-Mas, Margalida
Perelló-Reus, Catalina M.
Trias-Ferrer, Neus
Ibargüen-González, Lesly
Crespí, Catalina
Galmes-Panades, Aina Maria
Navas-Enamorado, Cayetano
Sanchez-Polo, Andres
Piérola-Lopetegui, Javier
Masmiquel, Luis
Crespi, Lorenzo Socias
Barcelo, Carles
Gonzalez-Freire, Marta
author_facet Torrens-Mas, Margalida
Perelló-Reus, Catalina M.
Trias-Ferrer, Neus
Ibargüen-González, Lesly
Crespí, Catalina
Galmes-Panades, Aina Maria
Navas-Enamorado, Cayetano
Sanchez-Polo, Andres
Piérola-Lopetegui, Javier
Masmiquel, Luis
Crespi, Lorenzo Socias
Barcelo, Carles
Gonzalez-Freire, Marta
author_sort Torrens-Mas, Margalida
collection PubMed
description Coronavirus disease 19 (COVID-19) is a persistent global pandemic with a very heterogeneous disease presentation ranging from a mild disease to dismal prognosis. Early detection of sensitivity and severity of COVID-19 is essential for the development of new treatments. In the present study, we measured the levels of circulating growth differentiation factor 15 (GDF15) and angiotensin-converting enzyme 2 (ACE2) in plasma of severity-stratified COVID-19 patients and uninfected control patients and characterized the in vitro effects and cohort frequency of ACE2 SNPs. Our results show that while circulating GDF15 and ACE2 stratify COVID-19 patients according to disease severity, ACE2 missense SNPs constitute a risk factor linked to infection susceptibility.
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spelling pubmed-93556742022-08-06 GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility Torrens-Mas, Margalida Perelló-Reus, Catalina M. Trias-Ferrer, Neus Ibargüen-González, Lesly Crespí, Catalina Galmes-Panades, Aina Maria Navas-Enamorado, Cayetano Sanchez-Polo, Andres Piérola-Lopetegui, Javier Masmiquel, Luis Crespi, Lorenzo Socias Barcelo, Carles Gonzalez-Freire, Marta Front Cell Infect Microbiol Cellular and Infection Microbiology Coronavirus disease 19 (COVID-19) is a persistent global pandemic with a very heterogeneous disease presentation ranging from a mild disease to dismal prognosis. Early detection of sensitivity and severity of COVID-19 is essential for the development of new treatments. In the present study, we measured the levels of circulating growth differentiation factor 15 (GDF15) and angiotensin-converting enzyme 2 (ACE2) in plasma of severity-stratified COVID-19 patients and uninfected control patients and characterized the in vitro effects and cohort frequency of ACE2 SNPs. Our results show that while circulating GDF15 and ACE2 stratify COVID-19 patients according to disease severity, ACE2 missense SNPs constitute a risk factor linked to infection susceptibility. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9355674/ /pubmed/35937703 http://dx.doi.org/10.3389/fcimb.2022.942951 Text en Copyright © 2022 Torrens-Mas, Perelló-Reus, Trias-Ferrer, Ibargüen-González, Crespí, Galmes-Panades, Navas-Enamorado, Sanchez-Polo, Piérola-Lopetegui, Masmiquel, Crespi, Barcelo and Gonzalez-Freire https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Torrens-Mas, Margalida
Perelló-Reus, Catalina M.
Trias-Ferrer, Neus
Ibargüen-González, Lesly
Crespí, Catalina
Galmes-Panades, Aina Maria
Navas-Enamorado, Cayetano
Sanchez-Polo, Andres
Piérola-Lopetegui, Javier
Masmiquel, Luis
Crespi, Lorenzo Socias
Barcelo, Carles
Gonzalez-Freire, Marta
GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility
title GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility
title_full GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility
title_fullStr GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility
title_full_unstemmed GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility
title_short GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility
title_sort gdf15 and ace2 stratify covid-19 patients according to severity while ace2 mutations increase infection susceptibility
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355674/
https://www.ncbi.nlm.nih.gov/pubmed/35937703
http://dx.doi.org/10.3389/fcimb.2022.942951
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