Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis

Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven by somatic driver mutations, affects over a third of people, yet remains poorly understood. Here we analyze genetic data from 200,453 UK Biobank participants to map the landscape of inherited predisposition t...

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Detalles Bibliográficos
Autores principales: Kar, Siddhartha P., Quiros, Pedro M., Gu, Muxin, Jiang, Tao, Mitchell, Jonathan, Langdon, Ryan, Iyer, Vivek, Barcena, Clea, Vijayabaskar, M. S., Fabre, Margarete A., Carter, Paul, Petrovski, Slavé, Burgess, Stephen, Vassiliou, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355874/
https://www.ncbi.nlm.nih.gov/pubmed/35835912
http://dx.doi.org/10.1038/s41588-022-01121-z

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