Hijacking of transcriptional condensates by endogenous retroviruses

Most endogenous retroviruses (ERVs) in mammals are incapable of retrotransposition; therefore, why ERV derepression is associated with lethality during early development has been a mystery. Here, we report that rapid and selective degradation of the heterochromatin adapter protein TRIM28 triggers di...

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Detalles Bibliográficos
Autores principales: Asimi, Vahid, Sampath Kumar, Abhishek, Niskanen, Henri, Riemenschneider, Christina, Hetzel, Sara, Naderi, Julian, Fasching, Nina, Popitsch, Niko, Du, Manyu, Kretzmer, Helene, Smith, Zachary D., Weigert, Raha, Walther, Maria, Mamde, Sainath, Meierhofer, David, Wittler, Lars, Buschow, René, Timmermann, Bernd, Cisse, Ibrahim I., Ameres, Stefan L., Meissner, Alexander, Hnisz, Denes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355880/
https://www.ncbi.nlm.nih.gov/pubmed/35864192
http://dx.doi.org/10.1038/s41588-022-01132-w

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