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Gemcitabine resistance of pancreatic cancer cells is mediated by IGF1R dependent upregulation of CD44 expression and isoform switching

Chemoresistance in pancreatic cancer cells may be caused by the expansion of inherently resistant cancer cells or by the adaptive plasticity of initially sensitive cancer cells. We investigated how CD44 isoforms switching contributed to gemcitabine resistance. Treating CD44 null/low single-cell clon...

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Detalles Bibliográficos
Autores principales:	Chen, Chen, Zhao, Shujie, Zhao, Xiangru, Cao, Lin, Karnad, Anand, Kumar, Addanki P., Freeman, James W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355957/ https://www.ncbi.nlm.nih.gov/pubmed/35931675 http://dx.doi.org/10.1038/s41419-022-05103-1

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