Allele-biased expression of the bovine APOB gene associated with the cholesterol deficiency defect suggests cis-regulatory enhancer effects of the LTR retrotransposon insertion

The insertion of an endogenous retroviral long terminal repeat (LTR) sequence into the bovine apolipoprotein B (APOB) gene is causal to the inherited genetic defect cholesterol deficiency (CD) observed in neonatal and young calves. Affected calves suffer from developmental abnormalities, symptoms of...

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Detalles Bibliográficos
Autores principales: Becker, Doreen, Weikard, Rosemarie, Heimes, Annika, Hadlich, Frieder, Hammon, Harald M., Meyerholz, Marie M., Petzl, Wolfram, Zerbe, Holm, Schuberth, Hans-Joachim, Hoedemaker, Martina, Schmicke, Marion, Engelmann, Susanne, Kühn, Christa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355974/
https://www.ncbi.nlm.nih.gov/pubmed/35931741
http://dx.doi.org/10.1038/s41598-022-17798-5

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