AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling

Adenoid cystic carcinoma (ACC) is an aggressive salivary gland malignancy with limited treatment options for recurrent or metastatic disease. Due to chemotherapy resistance and lack of targeted therapeutic approaches, current treatment options for the localized disease are limited to surgery and rad...

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Detalles Bibliográficos
Autores principales: Ferrarotto, Renata, Mishra, Vasudha, Herz, Elad, Yaacov, Adar, Solomon, Oz, Rauch, Rami, Mondshine, Adi, Motin, Maria, Leibovich-Rivkin, Tal, Davis, Matti, Kaye, Joel, Weber, Christopher R., Shen, Le, Pearson, Alexander T., Rosenberg, Ari J., Chen, Xiangying, Singh, Alka, Aster, Jon C., Agrawal, Nishant, Izumchenko, Evgeny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355983/
https://www.ncbi.nlm.nih.gov/pubmed/35931701
http://dx.doi.org/10.1038/s41419-022-05133-9

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