Regulatory T cells in skeletal muscle repair and regeneration: recent insights

Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a dynamic inflammatory microenvironment consisting of a complex network formed by the interaction of immune cells and their secreted cytokines. The homeostasis of the inflammatory microenvironment determines whe...

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Autores principales: Wu, Jianhui, Ren, Bowen, Wang, Daochao, Lin, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356005/
https://www.ncbi.nlm.nih.gov/pubmed/35931697
http://dx.doi.org/10.1038/s41419-022-05142-8
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author Wu, Jianhui
Ren, Bowen
Wang, Daochao
Lin, Hui
author_facet Wu, Jianhui
Ren, Bowen
Wang, Daochao
Lin, Hui
author_sort Wu, Jianhui
collection PubMed
description Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a dynamic inflammatory microenvironment consisting of a complex network formed by the interaction of immune cells and their secreted cytokines. The homeostasis of the inflammatory microenvironment determines whether skeletal muscle repair tissues will ultimately form scar tissue or regenerative tissue. Regulatory T cells (Tregs) regulate homeostasis within the immune system and self-immune tolerance, and play a crucial role in skeletal muscle repair and regeneration. Dysregulated Tregs function leads to abnormal repair. In this review, we discuss the role and mechanisms of Tregs in skeletal muscle repair and regeneration after injury and provide new strategies for Treg immunotherapy in skeletal muscle diseases.
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spelling pubmed-93560052022-08-07 Regulatory T cells in skeletal muscle repair and regeneration: recent insights Wu, Jianhui Ren, Bowen Wang, Daochao Lin, Hui Cell Death Dis Review Article Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a dynamic inflammatory microenvironment consisting of a complex network formed by the interaction of immune cells and their secreted cytokines. The homeostasis of the inflammatory microenvironment determines whether skeletal muscle repair tissues will ultimately form scar tissue or regenerative tissue. Regulatory T cells (Tregs) regulate homeostasis within the immune system and self-immune tolerance, and play a crucial role in skeletal muscle repair and regeneration. Dysregulated Tregs function leads to abnormal repair. In this review, we discuss the role and mechanisms of Tregs in skeletal muscle repair and regeneration after injury and provide new strategies for Treg immunotherapy in skeletal muscle diseases. Nature Publishing Group UK 2022-08-05 /pmc/articles/PMC9356005/ /pubmed/35931697 http://dx.doi.org/10.1038/s41419-022-05142-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Wu, Jianhui
Ren, Bowen
Wang, Daochao
Lin, Hui
Regulatory T cells in skeletal muscle repair and regeneration: recent insights
title Regulatory T cells in skeletal muscle repair and regeneration: recent insights
title_full Regulatory T cells in skeletal muscle repair and regeneration: recent insights
title_fullStr Regulatory T cells in skeletal muscle repair and regeneration: recent insights
title_full_unstemmed Regulatory T cells in skeletal muscle repair and regeneration: recent insights
title_short Regulatory T cells in skeletal muscle repair and regeneration: recent insights
title_sort regulatory t cells in skeletal muscle repair and regeneration: recent insights
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356005/
https://www.ncbi.nlm.nih.gov/pubmed/35931697
http://dx.doi.org/10.1038/s41419-022-05142-8
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