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Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9

In hypoxia and hyperglycemia, SET7/9 plays an important role in controlling HIF-1α methylation and regulating the transcription of HIF-1α target genes, which are responsible for angiogenesis and wound healing. Here, we report the Ir(III) complex Set7_1a bearing acetonitrile (ACN) ligands as a SET7/9...

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Detalles Bibliográficos
Autores principales:	Li, Guodong, Li, Dan, Wu, Chun, Li, Shengnan, Chen, Feng, Li, Peng, Ko, Chung-Nga, Wang, Wanhe, Lee, Simon Ming-Yuen, Lin, Ligen, Ma, Dik-Lung, Leung, Chung-Hang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356058/ https://www.ncbi.nlm.nih.gov/pubmed/35859119 http://dx.doi.org/10.1038/s12276-022-00804-1

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