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NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism

Nicotinamide adenine dinucleotide (NAD(+)) is an enzyme cofactor, co-substrate, and redox factor in all living cells and is necessary for maintaining cell metabolism. It has been shown that appropriate supplementation of NAD(+) precursors or inhibition of NAD(+)-depleting enzymes can promote mitocho...

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Autores principales: Ren, Zhongxiang, Xu, Yetong, Li, Tiejun, Sun, Weizhong, Tang, Zhiru, Wang, Yongsheng, Zhou, Kaifeng, Li, Jigang, Ding, Qi, Liang, Kaiyang, Wu, Liuting, Yin, Yulong, Sun, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356074/
https://www.ncbi.nlm.nih.gov/pubmed/35949199
http://dx.doi.org/10.1016/j.aninu.2022.06.009
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author Ren, Zhongxiang
Xu, Yetong
Li, Tiejun
Sun, Weizhong
Tang, Zhiru
Wang, Yongsheng
Zhou, Kaifeng
Li, Jigang
Ding, Qi
Liang, Kaiyang
Wu, Liuting
Yin, Yulong
Sun, Zhihong
author_facet Ren, Zhongxiang
Xu, Yetong
Li, Tiejun
Sun, Weizhong
Tang, Zhiru
Wang, Yongsheng
Zhou, Kaifeng
Li, Jigang
Ding, Qi
Liang, Kaiyang
Wu, Liuting
Yin, Yulong
Sun, Zhihong
author_sort Ren, Zhongxiang
collection PubMed
description Nicotinamide adenine dinucleotide (NAD(+)) is an enzyme cofactor, co-substrate, and redox factor in all living cells and is necessary for maintaining cell metabolism. It has been shown that appropriate supplementation of NAD(+) precursors or inhibition of NAD(+)-depleting enzymes can promote mitochondrial oxidative phosphorylation and improve host energy utilization efficiency. In addition, increasing evidence indicates that the gut microbiota plays a pivotal role in host metabolism. Theoretically, there should be a close correlation among NAD(+), gut microbiota, and host metabolism; however, the information is limited. In this review, we summarize the metabolic process of NAD(+) and its impact on host metabolism, the link between gut microbiota and host metabolism, as well as the potential effects of NAD(+) on microbial metabolism, providing a new perspective on the interaction between gut microbiota and host metabolism.
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spelling pubmed-93560742022-08-09 NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism Ren, Zhongxiang Xu, Yetong Li, Tiejun Sun, Weizhong Tang, Zhiru Wang, Yongsheng Zhou, Kaifeng Li, Jigang Ding, Qi Liang, Kaiyang Wu, Liuting Yin, Yulong Sun, Zhihong Anim Nutr Review Article Nicotinamide adenine dinucleotide (NAD(+)) is an enzyme cofactor, co-substrate, and redox factor in all living cells and is necessary for maintaining cell metabolism. It has been shown that appropriate supplementation of NAD(+) precursors or inhibition of NAD(+)-depleting enzymes can promote mitochondrial oxidative phosphorylation and improve host energy utilization efficiency. In addition, increasing evidence indicates that the gut microbiota plays a pivotal role in host metabolism. Theoretically, there should be a close correlation among NAD(+), gut microbiota, and host metabolism; however, the information is limited. In this review, we summarize the metabolic process of NAD(+) and its impact on host metabolism, the link between gut microbiota and host metabolism, as well as the potential effects of NAD(+) on microbial metabolism, providing a new perspective on the interaction between gut microbiota and host metabolism. KeAi Publishing 2022-06-22 /pmc/articles/PMC9356074/ /pubmed/35949199 http://dx.doi.org/10.1016/j.aninu.2022.06.009 Text en © 2022 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Ren, Zhongxiang
Xu, Yetong
Li, Tiejun
Sun, Weizhong
Tang, Zhiru
Wang, Yongsheng
Zhou, Kaifeng
Li, Jigang
Ding, Qi
Liang, Kaiyang
Wu, Liuting
Yin, Yulong
Sun, Zhihong
NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism
title NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism
title_full NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism
title_fullStr NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism
title_full_unstemmed NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism
title_short NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism
title_sort nad(+) and its possible role in gut microbiota: insights on the mechanisms by which gut microbes influence host metabolism
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356074/
https://www.ncbi.nlm.nih.gov/pubmed/35949199
http://dx.doi.org/10.1016/j.aninu.2022.06.009
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