Cargando…
NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism
Nicotinamide adenine dinucleotide (NAD(+)) is an enzyme cofactor, co-substrate, and redox factor in all living cells and is necessary for maintaining cell metabolism. It has been shown that appropriate supplementation of NAD(+) precursors or inhibition of NAD(+)-depleting enzymes can promote mitocho...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356074/ https://www.ncbi.nlm.nih.gov/pubmed/35949199 http://dx.doi.org/10.1016/j.aninu.2022.06.009 |
_version_ | 1784763437846364160 |
---|---|
author | Ren, Zhongxiang Xu, Yetong Li, Tiejun Sun, Weizhong Tang, Zhiru Wang, Yongsheng Zhou, Kaifeng Li, Jigang Ding, Qi Liang, Kaiyang Wu, Liuting Yin, Yulong Sun, Zhihong |
author_facet | Ren, Zhongxiang Xu, Yetong Li, Tiejun Sun, Weizhong Tang, Zhiru Wang, Yongsheng Zhou, Kaifeng Li, Jigang Ding, Qi Liang, Kaiyang Wu, Liuting Yin, Yulong Sun, Zhihong |
author_sort | Ren, Zhongxiang |
collection | PubMed |
description | Nicotinamide adenine dinucleotide (NAD(+)) is an enzyme cofactor, co-substrate, and redox factor in all living cells and is necessary for maintaining cell metabolism. It has been shown that appropriate supplementation of NAD(+) precursors or inhibition of NAD(+)-depleting enzymes can promote mitochondrial oxidative phosphorylation and improve host energy utilization efficiency. In addition, increasing evidence indicates that the gut microbiota plays a pivotal role in host metabolism. Theoretically, there should be a close correlation among NAD(+), gut microbiota, and host metabolism; however, the information is limited. In this review, we summarize the metabolic process of NAD(+) and its impact on host metabolism, the link between gut microbiota and host metabolism, as well as the potential effects of NAD(+) on microbial metabolism, providing a new perspective on the interaction between gut microbiota and host metabolism. |
format | Online Article Text |
id | pubmed-9356074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-93560742022-08-09 NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism Ren, Zhongxiang Xu, Yetong Li, Tiejun Sun, Weizhong Tang, Zhiru Wang, Yongsheng Zhou, Kaifeng Li, Jigang Ding, Qi Liang, Kaiyang Wu, Liuting Yin, Yulong Sun, Zhihong Anim Nutr Review Article Nicotinamide adenine dinucleotide (NAD(+)) is an enzyme cofactor, co-substrate, and redox factor in all living cells and is necessary for maintaining cell metabolism. It has been shown that appropriate supplementation of NAD(+) precursors or inhibition of NAD(+)-depleting enzymes can promote mitochondrial oxidative phosphorylation and improve host energy utilization efficiency. In addition, increasing evidence indicates that the gut microbiota plays a pivotal role in host metabolism. Theoretically, there should be a close correlation among NAD(+), gut microbiota, and host metabolism; however, the information is limited. In this review, we summarize the metabolic process of NAD(+) and its impact on host metabolism, the link between gut microbiota and host metabolism, as well as the potential effects of NAD(+) on microbial metabolism, providing a new perspective on the interaction between gut microbiota and host metabolism. KeAi Publishing 2022-06-22 /pmc/articles/PMC9356074/ /pubmed/35949199 http://dx.doi.org/10.1016/j.aninu.2022.06.009 Text en © 2022 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Ren, Zhongxiang Xu, Yetong Li, Tiejun Sun, Weizhong Tang, Zhiru Wang, Yongsheng Zhou, Kaifeng Li, Jigang Ding, Qi Liang, Kaiyang Wu, Liuting Yin, Yulong Sun, Zhihong NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism |
title | NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism |
title_full | NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism |
title_fullStr | NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism |
title_full_unstemmed | NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism |
title_short | NAD(+) and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism |
title_sort | nad(+) and its possible role in gut microbiota: insights on the mechanisms by which gut microbes influence host metabolism |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356074/ https://www.ncbi.nlm.nih.gov/pubmed/35949199 http://dx.doi.org/10.1016/j.aninu.2022.06.009 |
work_keys_str_mv | AT renzhongxiang nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism AT xuyetong nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism AT litiejun nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism AT sunweizhong nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism AT tangzhiru nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism AT wangyongsheng nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism AT zhoukaifeng nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism AT lijigang nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism AT dingqi nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism AT liangkaiyang nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism AT wuliuting nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism AT yinyulong nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism AT sunzhihong nadanditspossibleroleingutmicrobiotainsightsonthemechanismsbywhichgutmicrobesinfluencehostmetabolism |