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Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil
Hyptis martiusii Benth. also known as "cidreira brava", has some activities verified in the literature, such as antiulcerogenic, antimicrobial and antiedematogenic. This study aimed to verify the anti-inflammatory and antinociceptive effect of the leaves essential oil. For the evaluation o...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356156/ https://www.ncbi.nlm.nih.gov/pubmed/35942239 http://dx.doi.org/10.1016/j.btre.2022.e00756 |
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author | Barbosa, Andreza G.R. Tintino, Cícera D.M.O. Pessoa, Renata T. de Lacerda Neto, Luiz J. Martins, Anita O.B.P.B. de Oliveira, Maria R.C. Coutinho, Henrique D.M. Cruz-Martins, Natália Quintans Junior, Lucindo J. Wilairatana, Polrat de Menezes, Irwin R.A. |
author_facet | Barbosa, Andreza G.R. Tintino, Cícera D.M.O. Pessoa, Renata T. de Lacerda Neto, Luiz J. Martins, Anita O.B.P.B. de Oliveira, Maria R.C. Coutinho, Henrique D.M. Cruz-Martins, Natália Quintans Junior, Lucindo J. Wilairatana, Polrat de Menezes, Irwin R.A. |
author_sort | Barbosa, Andreza G.R. |
collection | PubMed |
description | Hyptis martiusii Benth. also known as "cidreira brava", has some activities verified in the literature, such as antiulcerogenic, antimicrobial and antiedematogenic. This study aimed to verify the anti-inflammatory and antinociceptive effect of the leaves essential oil. For the evaluation of the anti-inflammatory activity of OEHM (100 mg/kg/p.o.), models paw edema induced by dextran and histamine, peritonitis and vascular permeability were used. Regarding the anti-nociceptive activity of the OEHM, abdominal contortion tests by acetic acid, formalin, hot plate (50.75 and 100 mg/kg/p.o.), open field and mechanical plantar hyper-nociception (100 mg/kg/p.o.) were carried out. OEHM (100 mg/kg) showed anti-inflammatory activity, being able to remarkably deducing the paw edema induced by dextran and histamine, the total number of cell leukocytes/neutrophils in peritonitis, and exudate in vascular permeability. In antinociceptive activity, the OEHM did not promote significant effect in central nervous system in the open field assay, remarkably reduced abdominal contortions (50, 75 and 100 mg/kg), the time in the formalin assay and the mechanical hyper-nociception (100 mg/kg); however, only doses between 75 and 100 mg/kg were capable of ameliorating the reponse latency time. Regarding the probable mechanism of action, the antinociceptive activity includes the participation in the activation of opioid, TRPV1, and α2-noradrenergic systems. In short, data obtained here reveal that OEHM has anti-inflammatory and antinociceptive activity, implying that its action may be involved in the mechanism of inhibition or liberation of pro-inflammatory mediators involved in pain and inflammation. |
format | Online Article Text |
id | pubmed-9356156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-93561562022-08-07 Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil Barbosa, Andreza G.R. Tintino, Cícera D.M.O. Pessoa, Renata T. de Lacerda Neto, Luiz J. Martins, Anita O.B.P.B. de Oliveira, Maria R.C. Coutinho, Henrique D.M. Cruz-Martins, Natália Quintans Junior, Lucindo J. Wilairatana, Polrat de Menezes, Irwin R.A. Biotechnol Rep (Amst) Research Article Hyptis martiusii Benth. also known as "cidreira brava", has some activities verified in the literature, such as antiulcerogenic, antimicrobial and antiedematogenic. This study aimed to verify the anti-inflammatory and antinociceptive effect of the leaves essential oil. For the evaluation of the anti-inflammatory activity of OEHM (100 mg/kg/p.o.), models paw edema induced by dextran and histamine, peritonitis and vascular permeability were used. Regarding the anti-nociceptive activity of the OEHM, abdominal contortion tests by acetic acid, formalin, hot plate (50.75 and 100 mg/kg/p.o.), open field and mechanical plantar hyper-nociception (100 mg/kg/p.o.) were carried out. OEHM (100 mg/kg) showed anti-inflammatory activity, being able to remarkably deducing the paw edema induced by dextran and histamine, the total number of cell leukocytes/neutrophils in peritonitis, and exudate in vascular permeability. In antinociceptive activity, the OEHM did not promote significant effect in central nervous system in the open field assay, remarkably reduced abdominal contortions (50, 75 and 100 mg/kg), the time in the formalin assay and the mechanical hyper-nociception (100 mg/kg); however, only doses between 75 and 100 mg/kg were capable of ameliorating the reponse latency time. Regarding the probable mechanism of action, the antinociceptive activity includes the participation in the activation of opioid, TRPV1, and α2-noradrenergic systems. In short, data obtained here reveal that OEHM has anti-inflammatory and antinociceptive activity, implying that its action may be involved in the mechanism of inhibition or liberation of pro-inflammatory mediators involved in pain and inflammation. Elsevier 2022-07-23 /pmc/articles/PMC9356156/ /pubmed/35942239 http://dx.doi.org/10.1016/j.btre.2022.e00756 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Barbosa, Andreza G.R. Tintino, Cícera D.M.O. Pessoa, Renata T. de Lacerda Neto, Luiz J. Martins, Anita O.B.P.B. de Oliveira, Maria R.C. Coutinho, Henrique D.M. Cruz-Martins, Natália Quintans Junior, Lucindo J. Wilairatana, Polrat de Menezes, Irwin R.A. Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil |
title | Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil |
title_full | Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil |
title_fullStr | Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil |
title_full_unstemmed | Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil |
title_short | Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil |
title_sort | anti-inflammatory and antinociceptive effect of hyptis martiusii benth leaves essential oil |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356156/ https://www.ncbi.nlm.nih.gov/pubmed/35942239 http://dx.doi.org/10.1016/j.btre.2022.e00756 |
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