Role of the cystathionine β-synthase / H(2)S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome

BACKGROUND: Overexpression of the transsulfuration enzyme cystathionine-β-synthase (CBS), and overproduction of its product, hydrogen sulfide (H(2)S) are recognized as potential pathogenetic factors in Down syndrome (DS). The purpose of the study was to determine how the mitochondrial function and c...

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Detalles Bibliográficos
Autores principales: Panagaki, Theodora, Pecze, Laszlo, Randi, Elisa B., Nieminen, Anni I., Szabo, Csaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356176/
https://www.ncbi.nlm.nih.gov/pubmed/35921774
http://dx.doi.org/10.1016/j.redox.2022.102416

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