A single amino acid residue tunes the stability of the fully reduced flavin cofactor and photorepair activity in photolyases

The UV-induced DNA lesions, cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone photoproducts (6-4 photoproducts), can be directly photorepaired by CPD photolyases and 6-4 photolyases, respectively. The fully reduced flavin (hydroquinone, HQ) cofactor is required for the catalysis o...

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Detalles Bibliográficos
Autores principales: Wen, Bin, Xu, Lei, Tang, Yawei, Jiang, Zhen, Ge, Mengting, Liu, Li, Zhu, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356274/
https://www.ncbi.nlm.nih.gov/pubmed/35753350
http://dx.doi.org/10.1016/j.jbc.2022.102188

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