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A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2

CAG repeat expansions in the ATXN2 (ataxin-2) gene can cause the autosomal dominant disorder spinocerebellar ataxia type 2 (SCA2) as well as increase the risk of ALS. Abnormal molecular, motor, and neurophysiological phenotypes in SCA2 mouse models are normalized by lowering ATXN2 transcription, and...

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Detalles Bibliográficos
Autores principales:	Scoles, Daniel R., Gandelman, Mandi, Paul, Sharan, Dexheimer, Thomas, Dansithong, Warunee, Figueroa, Karla P., Pflieger, Lance T., Redlin, Scott, Kales, Stephen C., Sun, Hongmao, Maloney, David, Damoiseaux, Robert, Henderson, Mark J., Simeonov, Anton, Jadhav, Ajit, Pulst, Stefan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356275/ https://www.ncbi.nlm.nih.gov/pubmed/35787375 http://dx.doi.org/10.1016/j.jbc.2022.102228

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