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An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD

Siderophores are conditionally essential metabolites used by microbes for environmental iron sequestration. Most Streptomyces strains produce hydroxamate-based desferrioxamine (DFO) siderophores composed of repeating units of N(1)-hydroxy-cadaverine (or N(1)-hydroxy-putrescine) and succinate. The DF...

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Detalles Bibliográficos
Autores principales:	Yang, Jinping, Banas, Victoria S., Patel, Ketan D., Rivera, Gerry S.M., Mydy, Lisa S., Gulick, Andrew M., Wencewicz, Timothy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356276/ https://www.ncbi.nlm.nih.gov/pubmed/35750210 http://dx.doi.org/10.1016/j.jbc.2022.102166

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