Glycated ACE2 reduces anti-remodeling effects of renin-angiotensin system inhibition in human diabetic hearts

BACKGROUND: High glycated-hemoglobin (HbA1c) levels correlated with an elevated risk of adverse cardiovascular outcomes despite renin-angiotensin system (RAS) inhibition in type-2 diabetic (T2DM) patients with reduced ejection fraction. Using the routine biopsies of non-T2DM heart transplanted (HTX)...

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Detalles Bibliográficos
Autores principales: Marfella, Raffaele, D’Onofrio, Nunzia, Mansueto, Gelsomina, Grimaldi, Vincenzo, Trotta, Maria Consiglia, Sardu, Celestino, Sasso, Ferdinando Carlo, Scisciola, Lucia, Amarelli, Cristiano, Esposito, Salvatore, D’Amico, Michele, Golino, Paolo, De Feo, Marisa, Signoriello, Giuseppe, Paolisso, Pasquale, Gallinoro, Emanuele, Vanderheyden, Marc, Maiello, Ciro, Balestrieri, Maria Luisa, Barbato, Emanuele, Napoli, Claudio, Paolisso, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356400/
https://www.ncbi.nlm.nih.gov/pubmed/35932065
http://dx.doi.org/10.1186/s12933-022-01573-x

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