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Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold
BACKGROUND: Fe(3)O(4) nanoparticles are highly desired for constructing endogenous magnetic microenvironment in scaffold to accelerate bone regeneration due to their superior magnetism. However, their random arrangement easily leads to mutual consumption of magnetic poles, thereby weakening the magn...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356408/ https://www.ncbi.nlm.nih.gov/pubmed/35933507 http://dx.doi.org/10.1186/s40824-022-00278-2 |
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author | Shuai, Cijun Chen, Xuan He, Chongxian Qian, Guowen Shuai, Yang Peng, Shuping Deng, Youwen Yang, Wenjing |
author_facet | Shuai, Cijun Chen, Xuan He, Chongxian Qian, Guowen Shuai, Yang Peng, Shuping Deng, Youwen Yang, Wenjing |
author_sort | Shuai, Cijun |
collection | PubMed |
description | BACKGROUND: Fe(3)O(4) nanoparticles are highly desired for constructing endogenous magnetic microenvironment in scaffold to accelerate bone regeneration due to their superior magnetism. However, their random arrangement easily leads to mutual consumption of magnetic poles, thereby weakening the magnetic stimulation effect. METHODS: In this study, magnetic nanochains are synthesized by magnetic-field-guided interface co-assembly of Fe(3)O(4) nanoparticles. In detail, multiple Fe(3)O(4) nanoparticles are aligned along the direction of magnetic force lines and are connected in series to form nanochain structures under an external magnetic field. Subsequently, the nanochain structures are covered and fixed by depositing a thin layer of silica (SiO(2)), and consequently forming linear magnetic nanochains (Fe(3)O(4)@SiO(2)). The Fe(3)O(4)@SiO(2) nanochains are then incorporated into poly l-lactic acid (PLLA) scaffold prepared by selective laser sintering technology. RESULTS: The results show that the Fe(3)O(4)@SiO(2) nanochains with unique core–shell structure are successfully constructed. Meanwhile, the orderly assembly of nanoparticles in the Fe(3)O(4)@SiO(2) nanochains enable to form magnetic energy coupling and obtain a highly magnetic micro-field. The in vitro tests indicate that the PLLA/Fe(3)O(4)@SiO(2) scaffolds exhibit superior capacity in enhancing cell activity, improving osteogenesis-related gene expressions, and inducing cell mineralization compared with PLLA and PLLA/Fe(3)O(4) scaffolds. CONCLUSION: In short, the Fe(3)O(4)@SiO(2) nanochains endow scaffolds with good magnetism and cytocompatibility, which have great potential in accelerating bone repair. |
format | Online Article Text |
id | pubmed-9356408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-93564082022-08-07 Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold Shuai, Cijun Chen, Xuan He, Chongxian Qian, Guowen Shuai, Yang Peng, Shuping Deng, Youwen Yang, Wenjing Biomater Res Research Article BACKGROUND: Fe(3)O(4) nanoparticles are highly desired for constructing endogenous magnetic microenvironment in scaffold to accelerate bone regeneration due to their superior magnetism. However, their random arrangement easily leads to mutual consumption of magnetic poles, thereby weakening the magnetic stimulation effect. METHODS: In this study, magnetic nanochains are synthesized by magnetic-field-guided interface co-assembly of Fe(3)O(4) nanoparticles. In detail, multiple Fe(3)O(4) nanoparticles are aligned along the direction of magnetic force lines and are connected in series to form nanochain structures under an external magnetic field. Subsequently, the nanochain structures are covered and fixed by depositing a thin layer of silica (SiO(2)), and consequently forming linear magnetic nanochains (Fe(3)O(4)@SiO(2)). The Fe(3)O(4)@SiO(2) nanochains are then incorporated into poly l-lactic acid (PLLA) scaffold prepared by selective laser sintering technology. RESULTS: The results show that the Fe(3)O(4)@SiO(2) nanochains with unique core–shell structure are successfully constructed. Meanwhile, the orderly assembly of nanoparticles in the Fe(3)O(4)@SiO(2) nanochains enable to form magnetic energy coupling and obtain a highly magnetic micro-field. The in vitro tests indicate that the PLLA/Fe(3)O(4)@SiO(2) scaffolds exhibit superior capacity in enhancing cell activity, improving osteogenesis-related gene expressions, and inducing cell mineralization compared with PLLA and PLLA/Fe(3)O(4) scaffolds. CONCLUSION: In short, the Fe(3)O(4)@SiO(2) nanochains endow scaffolds with good magnetism and cytocompatibility, which have great potential in accelerating bone repair. BioMed Central 2022-08-06 /pmc/articles/PMC9356408/ /pubmed/35933507 http://dx.doi.org/10.1186/s40824-022-00278-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Shuai, Cijun Chen, Xuan He, Chongxian Qian, Guowen Shuai, Yang Peng, Shuping Deng, Youwen Yang, Wenjing Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
title | Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
title_full | Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
title_fullStr | Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
title_full_unstemmed | Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
title_short | Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
title_sort | construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356408/ https://www.ncbi.nlm.nih.gov/pubmed/35933507 http://dx.doi.org/10.1186/s40824-022-00278-2 |
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