Cargando…
Decline of onset-to-diagnosis interval and its impacts on clinical outcome of COVID-19 in China: a nation-wide observational study
BACKGROUND: To quantitatively assess the impact of the onset-to-diagnosis interval (ODI) on severity and death for coronavirus disease 2019 (COVID-19) patients. METHODS: This retrospective study was conducted based on the data on COVID-19 cases of China over the age of 40 years reported through Chin...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356511/ https://www.ncbi.nlm.nih.gov/pubmed/35931983 http://dx.doi.org/10.1186/s12879-022-07660-4 |
_version_ | 1784763535100739584 |
---|---|
author | Lu, Qing-Bin Che, Tian-Le Wang, Li-Ping Zhang, An-Ran Ren, Xiang Wang, Tao Geng, Meng-Jie Wang, Yi-Fei Liu, Meng-Yang Zhang, Hai-Yang Fang, Li-Qun Liu, Wei Li, Zhong-Jie |
author_facet | Lu, Qing-Bin Che, Tian-Le Wang, Li-Ping Zhang, An-Ran Ren, Xiang Wang, Tao Geng, Meng-Jie Wang, Yi-Fei Liu, Meng-Yang Zhang, Hai-Yang Fang, Li-Qun Liu, Wei Li, Zhong-Jie |
author_sort | Lu, Qing-Bin |
collection | PubMed |
description | BACKGROUND: To quantitatively assess the impact of the onset-to-diagnosis interval (ODI) on severity and death for coronavirus disease 2019 (COVID-19) patients. METHODS: This retrospective study was conducted based on the data on COVID-19 cases of China over the age of 40 years reported through China’s National Notifiable Infectious Disease Surveillance System from February 5, 2020 to October 8, 2020. The impacts of ODI on severe rate (SR) and case fatality rate (CFR) were evaluated at individual and population levels, which was further disaggregated by sex, age and geographic origin. RESULTS: As the rapid decline of ODI from around 40 days in early January to < 3 days in early March, both CFR and SR of COVID-19 largely dropped below 5% in China. After adjusting for age, sex, and region, an effect of ODI on SR was observed with the highest OR of 2.95 (95% CI 2.37‒3.66) at Day 10–11 and attributable fraction (AF) of 29.1% (95% CI 22.2‒36.1%) at Day 8–9. However, little effect of ODI on CFR was observed. Moreover, discrepancy of effect magnitude was found, showing a greater effect from ODI on SR among patients of male sex, younger age, and those cases in Wuhan. CONCLUSION: The ODI was significantly associated with the severity of COVID-19, highlighting the importance of timely diagnosis, especially for patients who were confirmed to gain increased benefit from early diagnosis to some extent. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-022-07660-4. |
format | Online Article Text |
id | pubmed-9356511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-93565112022-08-07 Decline of onset-to-diagnosis interval and its impacts on clinical outcome of COVID-19 in China: a nation-wide observational study Lu, Qing-Bin Che, Tian-Le Wang, Li-Ping Zhang, An-Ran Ren, Xiang Wang, Tao Geng, Meng-Jie Wang, Yi-Fei Liu, Meng-Yang Zhang, Hai-Yang Fang, Li-Qun Liu, Wei Li, Zhong-Jie BMC Infect Dis Research BACKGROUND: To quantitatively assess the impact of the onset-to-diagnosis interval (ODI) on severity and death for coronavirus disease 2019 (COVID-19) patients. METHODS: This retrospective study was conducted based on the data on COVID-19 cases of China over the age of 40 years reported through China’s National Notifiable Infectious Disease Surveillance System from February 5, 2020 to October 8, 2020. The impacts of ODI on severe rate (SR) and case fatality rate (CFR) were evaluated at individual and population levels, which was further disaggregated by sex, age and geographic origin. RESULTS: As the rapid decline of ODI from around 40 days in early January to < 3 days in early March, both CFR and SR of COVID-19 largely dropped below 5% in China. After adjusting for age, sex, and region, an effect of ODI on SR was observed with the highest OR of 2.95 (95% CI 2.37‒3.66) at Day 10–11 and attributable fraction (AF) of 29.1% (95% CI 22.2‒36.1%) at Day 8–9. However, little effect of ODI on CFR was observed. Moreover, discrepancy of effect magnitude was found, showing a greater effect from ODI on SR among patients of male sex, younger age, and those cases in Wuhan. CONCLUSION: The ODI was significantly associated with the severity of COVID-19, highlighting the importance of timely diagnosis, especially for patients who were confirmed to gain increased benefit from early diagnosis to some extent. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-022-07660-4. BioMed Central 2022-08-05 /pmc/articles/PMC9356511/ /pubmed/35931983 http://dx.doi.org/10.1186/s12879-022-07660-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Lu, Qing-Bin Che, Tian-Le Wang, Li-Ping Zhang, An-Ran Ren, Xiang Wang, Tao Geng, Meng-Jie Wang, Yi-Fei Liu, Meng-Yang Zhang, Hai-Yang Fang, Li-Qun Liu, Wei Li, Zhong-Jie Decline of onset-to-diagnosis interval and its impacts on clinical outcome of COVID-19 in China: a nation-wide observational study |
title | Decline of onset-to-diagnosis interval and its impacts on clinical outcome of COVID-19 in China: a nation-wide observational study |
title_full | Decline of onset-to-diagnosis interval and its impacts on clinical outcome of COVID-19 in China: a nation-wide observational study |
title_fullStr | Decline of onset-to-diagnosis interval and its impacts on clinical outcome of COVID-19 in China: a nation-wide observational study |
title_full_unstemmed | Decline of onset-to-diagnosis interval and its impacts on clinical outcome of COVID-19 in China: a nation-wide observational study |
title_short | Decline of onset-to-diagnosis interval and its impacts on clinical outcome of COVID-19 in China: a nation-wide observational study |
title_sort | decline of onset-to-diagnosis interval and its impacts on clinical outcome of covid-19 in china: a nation-wide observational study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356511/ https://www.ncbi.nlm.nih.gov/pubmed/35931983 http://dx.doi.org/10.1186/s12879-022-07660-4 |
work_keys_str_mv | AT luqingbin declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy AT chetianle declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy AT wangliping declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy AT zhanganran declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy AT renxiang declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy AT wangtao declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy AT gengmengjie declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy AT wangyifei declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy AT liumengyang declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy AT zhanghaiyang declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy AT fangliqun declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy AT liuwei declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy AT lizhongjie declineofonsettodiagnosisintervalanditsimpactsonclinicaloutcomeofcovid19inchinaanationwideobservationalstudy |