Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience
BACKGROUND: The soluble urokinase Plasminogen Activator Receptor (suPAR) has been identified as a reliable marker of COVID-19 severity, helping in personalizing COVID-19 therapy. This study aims to evaluate the correlation between suPAR levels and COVID-19 severity, in relation to the traditional in...
Autores principales: | , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356594/ https://www.ncbi.nlm.nih.gov/pubmed/35944880 http://dx.doi.org/10.1016/j.clim.2022.109091 |
_version_ | 1784763552883539968 |
---|---|
author | Infantino, Maria Morena, Lorenza Di Pietro, Massimo Antonio Romanin, Benedetta Cimolato, Barbara Rocca, Beatrice Anna Luisa Tunnera, Silvia Modi, Giulia Tilli, Marta Grossi, Valentina Lari, Barbara Cerutti, Helena Tesi, Giulia Anrò, Valentina Cartocci, Alessandra Benucci, Maurizio Veneziani, Francesca Casprini, Patrizia Manfredi, Mariangela |
author_facet | Infantino, Maria Morena, Lorenza Di Pietro, Massimo Antonio Romanin, Benedetta Cimolato, Barbara Rocca, Beatrice Anna Luisa Tunnera, Silvia Modi, Giulia Tilli, Marta Grossi, Valentina Lari, Barbara Cerutti, Helena Tesi, Giulia Anrò, Valentina Cartocci, Alessandra Benucci, Maurizio Veneziani, Francesca Casprini, Patrizia Manfredi, Mariangela |
author_sort | Infantino, Maria |
collection | PubMed |
description | BACKGROUND: The soluble urokinase Plasminogen Activator Receptor (suPAR) has been identified as a reliable marker of COVID-19 severity, helping in personalizing COVID-19 therapy. This study aims to evaluate the correlation between suPAR levels and COVID-19 severity, in relation to the traditional inflammatory markers. METHODS: Sera from 71 COVID-19 patients were tested for suPAR levels using Chorus suPAR assay (Diesse Diagnostica Senese SpA, Italy). suPAR levels were compared with other inflammatory markers: IL-1β, IL-6, TNF-α, circulating calprotectin, neutrophil and lymphocyte counts, and Neutrophil/Lymphocytes Ratio (NLR). Respiratory failure, expressed as P/F ratio, and mortality rate were used as indicators of disease severity. RESULTS: A positive correlation of suPAR levels with IL-6 (r = 0.479, p = 0.000), TNF-α (r = 0.348, p = 0.003), circulating calprotectin (r = 0.369, p = 0.002), neutrophil counts (r = 0.447, p = 0.001), NLR (r = 0.492, p = 0.001) has been shown. Stratifying COVID-19 population by suPAR concentration above and below 6 ng/mL, we observed higher levels of circulating calprotectin (10.1 μg/mL, SD 7.9 versus 6.4 μg/mL, SD 7.5, p < 0.001), higher levels of P/F ratio (207.5 IQR 188.3 vs 312.0 IQR 127.8, p = 0.013) and higher mortality rate. Median levels of suPAR were increased in all COVID-19 patients requiring additional respiratory support (Nasal Cannula, Venturi Mask, BPAP and CPAP) (6.5 IQR = 4.9) compared to the group at room air (4.6 IQR = 4.2). CONCLUSION: suPAR levels correlate with disease severity and survival rate of COVID-19 patients, representing a promising prognostic biomarker for the risk assessment of the disease. |
format | Online Article Text |
id | pubmed-9356594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93565942022-08-07 Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience Infantino, Maria Morena, Lorenza Di Pietro, Massimo Antonio Romanin, Benedetta Cimolato, Barbara Rocca, Beatrice Anna Luisa Tunnera, Silvia Modi, Giulia Tilli, Marta Grossi, Valentina Lari, Barbara Cerutti, Helena Tesi, Giulia Anrò, Valentina Cartocci, Alessandra Benucci, Maurizio Veneziani, Francesca Casprini, Patrizia Manfredi, Mariangela Clin Immunol Full Length Article BACKGROUND: The soluble urokinase Plasminogen Activator Receptor (suPAR) has been identified as a reliable marker of COVID-19 severity, helping in personalizing COVID-19 therapy. This study aims to evaluate the correlation between suPAR levels and COVID-19 severity, in relation to the traditional inflammatory markers. METHODS: Sera from 71 COVID-19 patients were tested for suPAR levels using Chorus suPAR assay (Diesse Diagnostica Senese SpA, Italy). suPAR levels were compared with other inflammatory markers: IL-1β, IL-6, TNF-α, circulating calprotectin, neutrophil and lymphocyte counts, and Neutrophil/Lymphocytes Ratio (NLR). Respiratory failure, expressed as P/F ratio, and mortality rate were used as indicators of disease severity. RESULTS: A positive correlation of suPAR levels with IL-6 (r = 0.479, p = 0.000), TNF-α (r = 0.348, p = 0.003), circulating calprotectin (r = 0.369, p = 0.002), neutrophil counts (r = 0.447, p = 0.001), NLR (r = 0.492, p = 0.001) has been shown. Stratifying COVID-19 population by suPAR concentration above and below 6 ng/mL, we observed higher levels of circulating calprotectin (10.1 μg/mL, SD 7.9 versus 6.4 μg/mL, SD 7.5, p < 0.001), higher levels of P/F ratio (207.5 IQR 188.3 vs 312.0 IQR 127.8, p = 0.013) and higher mortality rate. Median levels of suPAR were increased in all COVID-19 patients requiring additional respiratory support (Nasal Cannula, Venturi Mask, BPAP and CPAP) (6.5 IQR = 4.9) compared to the group at room air (4.6 IQR = 4.2). CONCLUSION: suPAR levels correlate with disease severity and survival rate of COVID-19 patients, representing a promising prognostic biomarker for the risk assessment of the disease. Elsevier Inc. 2022-09 2022-08-06 /pmc/articles/PMC9356594/ /pubmed/35944880 http://dx.doi.org/10.1016/j.clim.2022.109091 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Full Length Article Infantino, Maria Morena, Lorenza Di Pietro, Massimo Antonio Romanin, Benedetta Cimolato, Barbara Rocca, Beatrice Anna Luisa Tunnera, Silvia Modi, Giulia Tilli, Marta Grossi, Valentina Lari, Barbara Cerutti, Helena Tesi, Giulia Anrò, Valentina Cartocci, Alessandra Benucci, Maurizio Veneziani, Francesca Casprini, Patrizia Manfredi, Mariangela Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience |
title | Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience |
title_full | Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience |
title_fullStr | Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience |
title_full_unstemmed | Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience |
title_short | Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience |
title_sort | soluble urokinase plasminogen activator receptor (supar) levels are predictive of covid-19 severity: an italian experience |
topic | Full Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356594/ https://www.ncbi.nlm.nih.gov/pubmed/35944880 http://dx.doi.org/10.1016/j.clim.2022.109091 |
work_keys_str_mv | AT infantinomaria solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT morenalorenza solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT dipietromassimoantonio solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT romaninbenedetta solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT cimolatobarbara solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT roccabeatriceannaluisa solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT tunnerasilvia solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT modigiulia solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT tillimarta solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT grossivalentina solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT laribarbara solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT ceruttihelena solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT tesigiulia solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT anrovalentina solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT cartoccialessandra solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT benuccimaurizio solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT venezianifrancesca solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT casprinipatrizia solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience AT manfredimariangela solubleurokinaseplasminogenactivatorreceptorsuparlevelsarepredictiveofcovid19severityanitalianexperience |