Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience

BACKGROUND: The soluble urokinase Plasminogen Activator Receptor (suPAR) has been identified as a reliable marker of COVID-19 severity, helping in personalizing COVID-19 therapy. This study aims to evaluate the correlation between suPAR levels and COVID-19 severity, in relation to the traditional in...

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Autores principales: Infantino, Maria, Morena, Lorenza, Di Pietro, Massimo Antonio, Romanin, Benedetta, Cimolato, Barbara, Rocca, Beatrice Anna Luisa, Tunnera, Silvia, Modi, Giulia, Tilli, Marta, Grossi, Valentina, Lari, Barbara, Cerutti, Helena, Tesi, Giulia, Anrò, Valentina, Cartocci, Alessandra, Benucci, Maurizio, Veneziani, Francesca, Casprini, Patrizia, Manfredi, Mariangela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356594/
https://www.ncbi.nlm.nih.gov/pubmed/35944880
http://dx.doi.org/10.1016/j.clim.2022.109091
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author Infantino, Maria
Morena, Lorenza
Di Pietro, Massimo Antonio
Romanin, Benedetta
Cimolato, Barbara
Rocca, Beatrice Anna Luisa
Tunnera, Silvia
Modi, Giulia
Tilli, Marta
Grossi, Valentina
Lari, Barbara
Cerutti, Helena
Tesi, Giulia
Anrò, Valentina
Cartocci, Alessandra
Benucci, Maurizio
Veneziani, Francesca
Casprini, Patrizia
Manfredi, Mariangela
author_facet Infantino, Maria
Morena, Lorenza
Di Pietro, Massimo Antonio
Romanin, Benedetta
Cimolato, Barbara
Rocca, Beatrice Anna Luisa
Tunnera, Silvia
Modi, Giulia
Tilli, Marta
Grossi, Valentina
Lari, Barbara
Cerutti, Helena
Tesi, Giulia
Anrò, Valentina
Cartocci, Alessandra
Benucci, Maurizio
Veneziani, Francesca
Casprini, Patrizia
Manfredi, Mariangela
author_sort Infantino, Maria
collection PubMed
description BACKGROUND: The soluble urokinase Plasminogen Activator Receptor (suPAR) has been identified as a reliable marker of COVID-19 severity, helping in personalizing COVID-19 therapy. This study aims to evaluate the correlation between suPAR levels and COVID-19 severity, in relation to the traditional inflammatory markers. METHODS: Sera from 71 COVID-19 patients were tested for suPAR levels using Chorus suPAR assay (Diesse Diagnostica Senese SpA, Italy). suPAR levels were compared with other inflammatory markers: IL-1β, IL-6, TNF-α, circulating calprotectin, neutrophil and lymphocyte counts, and Neutrophil/Lymphocytes Ratio (NLR). Respiratory failure, expressed as P/F ratio, and mortality rate were used as indicators of disease severity. RESULTS: A positive correlation of suPAR levels with IL-6 (r = 0.479, p = 0.000), TNF-α (r = 0.348, p = 0.003), circulating calprotectin (r = 0.369, p = 0.002), neutrophil counts (r = 0.447, p = 0.001), NLR (r = 0.492, p = 0.001) has been shown. Stratifying COVID-19 population by suPAR concentration above and below 6 ng/mL, we observed higher levels of circulating calprotectin (10.1 μg/mL, SD 7.9 versus 6.4 μg/mL, SD 7.5, p < 0.001), higher levels of P/F ratio (207.5 IQR 188.3 vs 312.0 IQR 127.8, p = 0.013) and higher mortality rate. Median levels of suPAR were increased in all COVID-19 patients requiring additional respiratory support (Nasal Cannula, Venturi Mask, BPAP and CPAP) (6.5 IQR = 4.9) compared to the group at room air (4.6 IQR = 4.2). CONCLUSION: suPAR levels correlate with disease severity and survival rate of COVID-19 patients, representing a promising prognostic biomarker for the risk assessment of the disease.
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spelling pubmed-93565942022-08-07 Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience Infantino, Maria Morena, Lorenza Di Pietro, Massimo Antonio Romanin, Benedetta Cimolato, Barbara Rocca, Beatrice Anna Luisa Tunnera, Silvia Modi, Giulia Tilli, Marta Grossi, Valentina Lari, Barbara Cerutti, Helena Tesi, Giulia Anrò, Valentina Cartocci, Alessandra Benucci, Maurizio Veneziani, Francesca Casprini, Patrizia Manfredi, Mariangela Clin Immunol Full Length Article BACKGROUND: The soluble urokinase Plasminogen Activator Receptor (suPAR) has been identified as a reliable marker of COVID-19 severity, helping in personalizing COVID-19 therapy. This study aims to evaluate the correlation between suPAR levels and COVID-19 severity, in relation to the traditional inflammatory markers. METHODS: Sera from 71 COVID-19 patients were tested for suPAR levels using Chorus suPAR assay (Diesse Diagnostica Senese SpA, Italy). suPAR levels were compared with other inflammatory markers: IL-1β, IL-6, TNF-α, circulating calprotectin, neutrophil and lymphocyte counts, and Neutrophil/Lymphocytes Ratio (NLR). Respiratory failure, expressed as P/F ratio, and mortality rate were used as indicators of disease severity. RESULTS: A positive correlation of suPAR levels with IL-6 (r = 0.479, p = 0.000), TNF-α (r = 0.348, p = 0.003), circulating calprotectin (r = 0.369, p = 0.002), neutrophil counts (r = 0.447, p = 0.001), NLR (r = 0.492, p = 0.001) has been shown. Stratifying COVID-19 population by suPAR concentration above and below 6 ng/mL, we observed higher levels of circulating calprotectin (10.1 μg/mL, SD 7.9 versus 6.4 μg/mL, SD 7.5, p < 0.001), higher levels of P/F ratio (207.5 IQR 188.3 vs 312.0 IQR 127.8, p = 0.013) and higher mortality rate. Median levels of suPAR were increased in all COVID-19 patients requiring additional respiratory support (Nasal Cannula, Venturi Mask, BPAP and CPAP) (6.5 IQR = 4.9) compared to the group at room air (4.6 IQR = 4.2). CONCLUSION: suPAR levels correlate with disease severity and survival rate of COVID-19 patients, representing a promising prognostic biomarker for the risk assessment of the disease. Elsevier Inc. 2022-09 2022-08-06 /pmc/articles/PMC9356594/ /pubmed/35944880 http://dx.doi.org/10.1016/j.clim.2022.109091 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Full Length Article
Infantino, Maria
Morena, Lorenza
Di Pietro, Massimo Antonio
Romanin, Benedetta
Cimolato, Barbara
Rocca, Beatrice Anna Luisa
Tunnera, Silvia
Modi, Giulia
Tilli, Marta
Grossi, Valentina
Lari, Barbara
Cerutti, Helena
Tesi, Giulia
Anrò, Valentina
Cartocci, Alessandra
Benucci, Maurizio
Veneziani, Francesca
Casprini, Patrizia
Manfredi, Mariangela
Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience
title Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience
title_full Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience
title_fullStr Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience
title_full_unstemmed Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience
title_short Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience
title_sort soluble urokinase plasminogen activator receptor (supar) levels are predictive of covid-19 severity: an italian experience
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356594/
https://www.ncbi.nlm.nih.gov/pubmed/35944880
http://dx.doi.org/10.1016/j.clim.2022.109091
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