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Expression and Significance of TNF-α and NF-κB/p65 in Cutaneous Lichen Planus

PURPOSE: The purpose of this study was to explore the expression of TNF-α and NF-κB/p65 in Lichen planus skin lesions and their correlation with the pathogenesis of Lichen planus. PATIENTS AND METHODS: The case group consisted of 30 individuals diagnosed with LP based on clinical and histopathologic...

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Autores principales: Chen, Jun Fang, Zhang, Xue Mei, Sanjel, Kiran, Zhang, Juan, Ma, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356624/
https://www.ncbi.nlm.nih.gov/pubmed/35941857
http://dx.doi.org/10.2147/CCID.S372662
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author Chen, Jun Fang
Zhang, Xue Mei
Sanjel, Kiran
Zhang, Juan
Ma, Cong
author_facet Chen, Jun Fang
Zhang, Xue Mei
Sanjel, Kiran
Zhang, Juan
Ma, Cong
author_sort Chen, Jun Fang
collection PubMed
description PURPOSE: The purpose of this study was to explore the expression of TNF-α and NF-κB/p65 in Lichen planus skin lesions and their correlation with the pathogenesis of Lichen planus. PATIENTS AND METHODS: The case group consisted of 30 individuals diagnosed with LP based on clinical and histopathologic examination. The control group consisted of 10 individuals from an Orthopedic Department with normal skin. TNF-α and NF-κB/p65 expression in skin tissue samples was detected by immunohistochemistry. RESULTS: The immunohistochemical results showed that TNF-α and NF-κB/p65 expression levels were significantly higher in LP skin lesions than normal skin tissues (P ≤ 0.05). Positive TNF-α staining mainly occurred in the cytoplasm of keratinocytes of the stratum granulosum, stratum spinosum, and stratum basale in the epidermis and lymphocytes in the superficial dermis. Positive NF-κB/p65 staining mainly occurred in the nucleus and cytoplasm of keratinocytes of the stratum spinosum and stratum basale in the epidermis and lymphocytes in the superficial dermis. CONCLUSION: TNF-α and NF-κB/p65 are overexpressed in cutaneous LP. The two are positively correlated in LP, suggesting that they both play essential roles in the pathogenesis of LP.
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spelling pubmed-93566242022-08-07 Expression and Significance of TNF-α and NF-κB/p65 in Cutaneous Lichen Planus Chen, Jun Fang Zhang, Xue Mei Sanjel, Kiran Zhang, Juan Ma, Cong Clin Cosmet Investig Dermatol Original Research PURPOSE: The purpose of this study was to explore the expression of TNF-α and NF-κB/p65 in Lichen planus skin lesions and their correlation with the pathogenesis of Lichen planus. PATIENTS AND METHODS: The case group consisted of 30 individuals diagnosed with LP based on clinical and histopathologic examination. The control group consisted of 10 individuals from an Orthopedic Department with normal skin. TNF-α and NF-κB/p65 expression in skin tissue samples was detected by immunohistochemistry. RESULTS: The immunohistochemical results showed that TNF-α and NF-κB/p65 expression levels were significantly higher in LP skin lesions than normal skin tissues (P ≤ 0.05). Positive TNF-α staining mainly occurred in the cytoplasm of keratinocytes of the stratum granulosum, stratum spinosum, and stratum basale in the epidermis and lymphocytes in the superficial dermis. Positive NF-κB/p65 staining mainly occurred in the nucleus and cytoplasm of keratinocytes of the stratum spinosum and stratum basale in the epidermis and lymphocytes in the superficial dermis. CONCLUSION: TNF-α and NF-κB/p65 are overexpressed in cutaneous LP. The two are positively correlated in LP, suggesting that they both play essential roles in the pathogenesis of LP. Dove 2022-08-02 /pmc/articles/PMC9356624/ /pubmed/35941857 http://dx.doi.org/10.2147/CCID.S372662 Text en © 2022 Chen et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Chen, Jun Fang
Zhang, Xue Mei
Sanjel, Kiran
Zhang, Juan
Ma, Cong
Expression and Significance of TNF-α and NF-κB/p65 in Cutaneous Lichen Planus
title Expression and Significance of TNF-α and NF-κB/p65 in Cutaneous Lichen Planus
title_full Expression and Significance of TNF-α and NF-κB/p65 in Cutaneous Lichen Planus
title_fullStr Expression and Significance of TNF-α and NF-κB/p65 in Cutaneous Lichen Planus
title_full_unstemmed Expression and Significance of TNF-α and NF-κB/p65 in Cutaneous Lichen Planus
title_short Expression and Significance of TNF-α and NF-κB/p65 in Cutaneous Lichen Planus
title_sort expression and significance of tnf-α and nf-κb/p65 in cutaneous lichen planus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356624/
https://www.ncbi.nlm.nih.gov/pubmed/35941857
http://dx.doi.org/10.2147/CCID.S372662
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