Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States

A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated wi...

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Detalles Bibliográficos
Autores principales: Matias, Wilfredo R, Koshy, Jacob M, Nagami, Ellen H, Kovac, Victor, Moeng, Letumile R, Shenoy, Erica S, Hooper, David C, Madoff, Lawrence C, Barshak, Miriam B, Johnson, Jennifer A, Rowley, Christopher F, Julg, Boris, Hohmann, Elizabeth L, Lazarus, Jacob E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356679/
https://www.ncbi.nlm.nih.gov/pubmed/35949403
http://dx.doi.org/10.1093/ofid/ofac377
Descripción
Sumario:A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated with tecovirimat, a pan-Orthopoxvirus inhibitor currently available under an expanded access investigational new drug protocol for monkeypox.

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