Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States

A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated wi...

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Autores principales: Matias, Wilfredo R, Koshy, Jacob M, Nagami, Ellen H, Kovac, Victor, Moeng, Letumile R, Shenoy, Erica S, Hooper, David C, Madoff, Lawrence C, Barshak, Miriam B, Johnson, Jennifer A, Rowley, Christopher F, Julg, Boris, Hohmann, Elizabeth L, Lazarus, Jacob E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356679/
https://www.ncbi.nlm.nih.gov/pubmed/35949403
http://dx.doi.org/10.1093/ofid/ofac377
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author Matias, Wilfredo R
Koshy, Jacob M
Nagami, Ellen H
Kovac, Victor
Moeng, Letumile R
Shenoy, Erica S
Hooper, David C
Madoff, Lawrence C
Barshak, Miriam B
Johnson, Jennifer A
Rowley, Christopher F
Julg, Boris
Hohmann, Elizabeth L
Lazarus, Jacob E
author_facet Matias, Wilfredo R
Koshy, Jacob M
Nagami, Ellen H
Kovac, Victor
Moeng, Letumile R
Shenoy, Erica S
Hooper, David C
Madoff, Lawrence C
Barshak, Miriam B
Johnson, Jennifer A
Rowley, Christopher F
Julg, Boris
Hohmann, Elizabeth L
Lazarus, Jacob E
author_sort Matias, Wilfredo R
collection PubMed
description A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated with tecovirimat, a pan-Orthopoxvirus inhibitor currently available under an expanded access investigational new drug protocol for monkeypox.
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spelling pubmed-93566792022-08-09 Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States Matias, Wilfredo R Koshy, Jacob M Nagami, Ellen H Kovac, Victor Moeng, Letumile R Shenoy, Erica S Hooper, David C Madoff, Lawrence C Barshak, Miriam B Johnson, Jennifer A Rowley, Christopher F Julg, Boris Hohmann, Elizabeth L Lazarus, Jacob E Open Forum Infect Dis Brief Report A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated with tecovirimat, a pan-Orthopoxvirus inhibitor currently available under an expanded access investigational new drug protocol for monkeypox. Oxford University Press 2022-07-27 /pmc/articles/PMC9356679/ /pubmed/35949403 http://dx.doi.org/10.1093/ofid/ofac377 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Matias, Wilfredo R
Koshy, Jacob M
Nagami, Ellen H
Kovac, Victor
Moeng, Letumile R
Shenoy, Erica S
Hooper, David C
Madoff, Lawrence C
Barshak, Miriam B
Johnson, Jennifer A
Rowley, Christopher F
Julg, Boris
Hohmann, Elizabeth L
Lazarus, Jacob E
Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States
title Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States
title_full Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States
title_fullStr Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States
title_full_unstemmed Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States
title_short Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States
title_sort tecovirimat for the treatment of human monkeypox: an initial series from massachusetts, united states
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356679/
https://www.ncbi.nlm.nih.gov/pubmed/35949403
http://dx.doi.org/10.1093/ofid/ofac377
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