A Secondary Metabolic Enzyme Functioned as an Evolutionary Seed of a Primary Metabolic Enzyme

The antibiotic alaremycin has a structure that resembles that of 5-aminolevulinic acid (ALA), a universal precursor of porphyrins, and inhibits porphyrin biosynthesis. Genome sequencing of the alaremycin-producing bacterial strain and enzymatic analysis revealed that the first step of alaremcyin bio...

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Detalles Bibliográficos
Autores principales: Kawaguchi, Jun, Mori, Hikaru, Iwai, Noritaka, Wachi, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356726/
https://www.ncbi.nlm.nih.gov/pubmed/35904937
http://dx.doi.org/10.1093/molbev/msac164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356726/
https://www.ncbi.nlm.nih.gov/pubmed/35904937
http://dx.doi.org/10.1093/molbev/msac164

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