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Evolution of Human-Specific Alleles Protecting Cognitive Function of Grandmothers

The myelomonocytic receptor CD33 (Siglec-3) inhibits innate immune reactivity by extracellular V-set domain recognition of sialic acid (Sia)-containing “self-associated molecular patterns” (SAMPs). We earlier showed that V-set domain-deficient CD33-variant allele, protective against late-onset Alzhe...

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Detalles Bibliográficos
Autores principales:	Saha, Sudeshna, Khan, Naazneen, Comi, Troy, Verhagen, Andrea, Sasmal, Aniruddha, Diaz, Sandra, Yu, Hai, Chen, Xi, Akey, Joshua M, Frank, Martin, Gagneux, Pascal, Varki, Ajit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Discoveries
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356730/ https://www.ncbi.nlm.nih.gov/pubmed/35809046 http://dx.doi.org/10.1093/molbev/msac151

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