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Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review

OBJECTIVE: This study systematically reviewed recent findings on neurocognitive functioning and health-related quality of life (HRQoL) of children after pediatric intensive care unit admission (PICU). DATA SOURCES: Electronic databases searched included Embase, Medline Ovid, Web of Science, Cochrane...

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Autores principales: Hordijk, José A., Verbruggen, Sascha C., Buysse, Corinne M., Utens, Elisabeth M., Joosten, Koen F., Dulfer, Karolijn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356943/
https://www.ncbi.nlm.nih.gov/pubmed/35357629
http://dx.doi.org/10.1007/s11136-022-03124-z
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author Hordijk, José A.
Verbruggen, Sascha C.
Buysse, Corinne M.
Utens, Elisabeth M.
Joosten, Koen F.
Dulfer, Karolijn
author_facet Hordijk, José A.
Verbruggen, Sascha C.
Buysse, Corinne M.
Utens, Elisabeth M.
Joosten, Koen F.
Dulfer, Karolijn
author_sort Hordijk, José A.
collection PubMed
description OBJECTIVE: This study systematically reviewed recent findings on neurocognitive functioning and health-related quality of life (HRQoL) of children after pediatric intensive care unit admission (PICU). DATA SOURCES: Electronic databases searched included Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar. The search was limited to studies published in the last five years (2015–2019). STUDY SELECTION: Original studies assessing neurocognitive functioning or HRQoL in children who were previously admitted to the PICU were included in this systematic review. DATA EXTRACTION: Of the 3649 identified studies, 299 met the inclusion criteria based on title abstract screening. After full-text screening, 75 articles were included in the qualitative data reviewing: 38 on neurocognitive functioning, 33 on HRQoL, and 4 on both outcomes. DATA SYNTHESIS: Studies examining neurocognitive functioning found overall worse scores for general intellectual functioning, attention, processing speed, memory, and executive functioning. Studies investigating HRQoL found overall worse scores for both physical and psychosocial HRQoL. On the short term (≤ 12 months), most studies reported HRQoL impairments, whereas in some long-term studies HRQoL normalized. The effectiveness of the few intervention studies during and after PICU admission on long-term outcomes varied. CONCLUSIONS: PICU survivors have lower scores for neurocognitive functioning and HRQoL than children from the general population. A structured follow-up program after a PICU admission is needed to identify those children and parents who are at risk. However, more research is needed into testing interventions in randomized controlled trials aiming on preventing or improving impairments in critically ill children during and after PICU admission. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11136-022-03124-z.
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spelling pubmed-93569432022-08-08 Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review Hordijk, José A. Verbruggen, Sascha C. Buysse, Corinne M. Utens, Elisabeth M. Joosten, Koen F. Dulfer, Karolijn Qual Life Res Review OBJECTIVE: This study systematically reviewed recent findings on neurocognitive functioning and health-related quality of life (HRQoL) of children after pediatric intensive care unit admission (PICU). DATA SOURCES: Electronic databases searched included Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar. The search was limited to studies published in the last five years (2015–2019). STUDY SELECTION: Original studies assessing neurocognitive functioning or HRQoL in children who were previously admitted to the PICU were included in this systematic review. DATA EXTRACTION: Of the 3649 identified studies, 299 met the inclusion criteria based on title abstract screening. After full-text screening, 75 articles were included in the qualitative data reviewing: 38 on neurocognitive functioning, 33 on HRQoL, and 4 on both outcomes. DATA SYNTHESIS: Studies examining neurocognitive functioning found overall worse scores for general intellectual functioning, attention, processing speed, memory, and executive functioning. Studies investigating HRQoL found overall worse scores for both physical and psychosocial HRQoL. On the short term (≤ 12 months), most studies reported HRQoL impairments, whereas in some long-term studies HRQoL normalized. The effectiveness of the few intervention studies during and after PICU admission on long-term outcomes varied. CONCLUSIONS: PICU survivors have lower scores for neurocognitive functioning and HRQoL than children from the general population. A structured follow-up program after a PICU admission is needed to identify those children and parents who are at risk. However, more research is needed into testing interventions in randomized controlled trials aiming on preventing or improving impairments in critically ill children during and after PICU admission. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11136-022-03124-z. Springer International Publishing 2022-03-31 2022 /pmc/articles/PMC9356943/ /pubmed/35357629 http://dx.doi.org/10.1007/s11136-022-03124-z Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Hordijk, José A.
Verbruggen, Sascha C.
Buysse, Corinne M.
Utens, Elisabeth M.
Joosten, Koen F.
Dulfer, Karolijn
Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review
title Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review
title_full Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review
title_fullStr Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review
title_full_unstemmed Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review
title_short Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review
title_sort neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356943/
https://www.ncbi.nlm.nih.gov/pubmed/35357629
http://dx.doi.org/10.1007/s11136-022-03124-z
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