Cargando…
Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season
This research evaluates the effect of dietary zinc oxide nanoparticles’ (ZnO NPs) supplementation on growth performance, immunity, oxidative antioxidative properties, and histopathological picture of broiler chicken reared in the summer season. A total of 224 1-day-old male Cobb chicks were randomly...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356964/ https://www.ncbi.nlm.nih.gov/pubmed/35292898 http://dx.doi.org/10.1007/s11356-022-19156-4 |
_version_ | 1784763642984529920 |
---|---|
author | Dosoky, Waleed M. Al-Banna, Aya A. Zahran, Soliman M. Farag, Soha A. Abdelsalam, Nader R. Khafaga, Asmaa F. |
author_facet | Dosoky, Waleed M. Al-Banna, Aya A. Zahran, Soliman M. Farag, Soha A. Abdelsalam, Nader R. Khafaga, Asmaa F. |
author_sort | Dosoky, Waleed M. |
collection | PubMed |
description | This research evaluates the effect of dietary zinc oxide nanoparticles’ (ZnO NPs) supplementation on growth performance, immunity, oxidative antioxidative properties, and histopathological picture of broiler chicken reared in the summer season. A total of 224 1-day-old male Cobb chicks were randomly allocated to seven groups of dietary treatments (n = 32). Seven isocaloric and isonitrogenous diets were formulated. ZnO NPs were added to the basal diet at seven different levels, 0, 5, 10, 20, 40, 60, and 80 ppm/kg diet, respectively, for 35 days. Results indicated that live body weight (g) did not differ significantly (P > 0.05) between treatment groups, whereas compared to control, the 5 ppm ZnO NPs/kg diet recorded the highest live body weight at 21 and 35 days. No significant effects for the feed consumption (g/bird/period) and feed conversion ratio (g feed/g gain) among treated and control birds were observed. Hematological and immunological variables showed significant (P ≤ 0.05) dose-dependent modulations by ZnO NP supplementation. Significant (P ≤ 0.05) differences were observed in the phagocytic activity, phagocytic index, and IgM and IgG between the treatment groups, with the 5 and 10 ppm ZnO NPs/kg diet recording the best values, followed by the 20 ppm ZnO NPs/kg diet. Different supplementations had nonsignificant effects on the digestibility of nutrients (P ≤ 0.05). Histopathological pictures of the kidney, liver, and lymphoid organs, ultrastructural examination of muscle tissues, and expression of inflammatory cytokines showed dose-dependent morphological and structural changes. In conclusion, the ZnO NP supplementation in broiler diet to eliminate the heat stress hazards in summer season is recommended in dose level of not more than 10 ppm/kg diet. |
format | Online Article Text |
id | pubmed-9356964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-93569642022-08-08 Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season Dosoky, Waleed M. Al-Banna, Aya A. Zahran, Soliman M. Farag, Soha A. Abdelsalam, Nader R. Khafaga, Asmaa F. Environ Sci Pollut Res Int Research Article This research evaluates the effect of dietary zinc oxide nanoparticles’ (ZnO NPs) supplementation on growth performance, immunity, oxidative antioxidative properties, and histopathological picture of broiler chicken reared in the summer season. A total of 224 1-day-old male Cobb chicks were randomly allocated to seven groups of dietary treatments (n = 32). Seven isocaloric and isonitrogenous diets were formulated. ZnO NPs were added to the basal diet at seven different levels, 0, 5, 10, 20, 40, 60, and 80 ppm/kg diet, respectively, for 35 days. Results indicated that live body weight (g) did not differ significantly (P > 0.05) between treatment groups, whereas compared to control, the 5 ppm ZnO NPs/kg diet recorded the highest live body weight at 21 and 35 days. No significant effects for the feed consumption (g/bird/period) and feed conversion ratio (g feed/g gain) among treated and control birds were observed. Hematological and immunological variables showed significant (P ≤ 0.05) dose-dependent modulations by ZnO NP supplementation. Significant (P ≤ 0.05) differences were observed in the phagocytic activity, phagocytic index, and IgM and IgG between the treatment groups, with the 5 and 10 ppm ZnO NPs/kg diet recording the best values, followed by the 20 ppm ZnO NPs/kg diet. Different supplementations had nonsignificant effects on the digestibility of nutrients (P ≤ 0.05). Histopathological pictures of the kidney, liver, and lymphoid organs, ultrastructural examination of muscle tissues, and expression of inflammatory cytokines showed dose-dependent morphological and structural changes. In conclusion, the ZnO NP supplementation in broiler diet to eliminate the heat stress hazards in summer season is recommended in dose level of not more than 10 ppm/kg diet. Springer Berlin Heidelberg 2022-03-16 2022 /pmc/articles/PMC9356964/ /pubmed/35292898 http://dx.doi.org/10.1007/s11356-022-19156-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Dosoky, Waleed M. Al-Banna, Aya A. Zahran, Soliman M. Farag, Soha A. Abdelsalam, Nader R. Khafaga, Asmaa F. Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season |
title | Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season |
title_full | Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season |
title_fullStr | Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season |
title_full_unstemmed | Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season |
title_short | Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season |
title_sort | zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356964/ https://www.ncbi.nlm.nih.gov/pubmed/35292898 http://dx.doi.org/10.1007/s11356-022-19156-4 |
work_keys_str_mv | AT dosokywaleedm zincoxidenanoparticlesinducedosedependenttoxicosisinbroilerchickensrearedinsummerseason AT albannaayaa zincoxidenanoparticlesinducedosedependenttoxicosisinbroilerchickensrearedinsummerseason AT zahransolimanm zincoxidenanoparticlesinducedosedependenttoxicosisinbroilerchickensrearedinsummerseason AT faragsohaa zincoxidenanoparticlesinducedosedependenttoxicosisinbroilerchickensrearedinsummerseason AT abdelsalamnaderr zincoxidenanoparticlesinducedosedependenttoxicosisinbroilerchickensrearedinsummerseason AT khafagaasmaaf zincoxidenanoparticlesinducedosedependenttoxicosisinbroilerchickensrearedinsummerseason |