Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis

BACKGROUND: Retinoblastoma binding protein 4 (Rbbp4) is a component of transcription regulatory complexes that control cell cycle gene expression. Previous work indicated that Rbbp4 cooperates with the Rb tumor suppressor to block cell cycle entry. Here, we use genetic analysis to examine the intera...

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Detalles Bibliográficos
Autores principales: Schultz‐Rogers, Laura E., Thayer, Michelle L., Kambakam, Sekhar, Wierson, Wesley A., Helmer, Jordan A., Wishman, Mark D., Wall, Kristen A., Greig, Jessica L., Forsman, Jaimie L., Puchhalapalli, Kavya, Nair, Siddharth, Weiss, Trevor J., Luiken, Jon M., Blackburn, Patrick R., Ekker, Stephen C., Kool, Marcel, McGrail, Maura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356990/
https://www.ncbi.nlm.nih.gov/pubmed/35266256
http://dx.doi.org/10.1002/dvdy.467

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