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mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant

The SARS-CoV-2 Omicron variant evades vaccine-induced immunity. While a booster dose of ancestral mRNA vaccines effectively elicits neutralizing antibodies against variants, its efficacy against Omicron in older adults, who are at the greatest risk of severe disease, is not fully elucidated. Here, w...

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Autores principales: Nanishi, Etsuro, McGrath, Marisa E., O’Meara, Timothy R., Barman, Soumik, Yu, Jingyou, Wan, Huahua, Dillen, Carly A., Menon, Manisha, Seo, Hyuk-Soo, Song, Kijun, Xu, Andrew Z., Sebastian, Luke, Brook, Byron, Bosco, Anna-Nicole, Borriello, Francesco, Ernst, Robert K., Barouch, Dan H., Dhe-Paganon, Sirano, Levy, Ofer, Frieman, Matthew B., Dowling, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357006/
https://www.ncbi.nlm.nih.gov/pubmed/35933439
http://dx.doi.org/10.1038/s42003-022-03765-3
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author Nanishi, Etsuro
McGrath, Marisa E.
O’Meara, Timothy R.
Barman, Soumik
Yu, Jingyou
Wan, Huahua
Dillen, Carly A.
Menon, Manisha
Seo, Hyuk-Soo
Song, Kijun
Xu, Andrew Z.
Sebastian, Luke
Brook, Byron
Bosco, Anna-Nicole
Borriello, Francesco
Ernst, Robert K.
Barouch, Dan H.
Dhe-Paganon, Sirano
Levy, Ofer
Frieman, Matthew B.
Dowling, David J.
author_facet Nanishi, Etsuro
McGrath, Marisa E.
O’Meara, Timothy R.
Barman, Soumik
Yu, Jingyou
Wan, Huahua
Dillen, Carly A.
Menon, Manisha
Seo, Hyuk-Soo
Song, Kijun
Xu, Andrew Z.
Sebastian, Luke
Brook, Byron
Bosco, Anna-Nicole
Borriello, Francesco
Ernst, Robert K.
Barouch, Dan H.
Dhe-Paganon, Sirano
Levy, Ofer
Frieman, Matthew B.
Dowling, David J.
author_sort Nanishi, Etsuro
collection PubMed
description The SARS-CoV-2 Omicron variant evades vaccine-induced immunity. While a booster dose of ancestral mRNA vaccines effectively elicits neutralizing antibodies against variants, its efficacy against Omicron in older adults, who are at the greatest risk of severe disease, is not fully elucidated. Here, we evaluate multiple longitudinal immunization regimens of mRNA BNT162b2 to assess the effects of a booster dose provided >8 months after the primary immunization series across the murine lifespan, including in aged 21-month-old mice. Boosting dramatically enhances humoral and cell-mediated responses with evidence of Omicron cross-recognition. Furthermore, while younger mice are protected without a booster dose, boosting provides sterilizing immunity against Omicron-induced lung infection in aged 21-month-old mice. Correlational analyses reveal that neutralizing activity against Omicron is strongly associated with protection. Overall, our findings indicate age-dependent vaccine efficacy and demonstrate the potential benefit of mRNA booster immunization to protect vulnerable older populations against SARS-CoV-2 variants.
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spelling pubmed-93570062022-08-08 mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant Nanishi, Etsuro McGrath, Marisa E. O’Meara, Timothy R. Barman, Soumik Yu, Jingyou Wan, Huahua Dillen, Carly A. Menon, Manisha Seo, Hyuk-Soo Song, Kijun Xu, Andrew Z. Sebastian, Luke Brook, Byron Bosco, Anna-Nicole Borriello, Francesco Ernst, Robert K. Barouch, Dan H. Dhe-Paganon, Sirano Levy, Ofer Frieman, Matthew B. Dowling, David J. Commun Biol Article The SARS-CoV-2 Omicron variant evades vaccine-induced immunity. While a booster dose of ancestral mRNA vaccines effectively elicits neutralizing antibodies against variants, its efficacy against Omicron in older adults, who are at the greatest risk of severe disease, is not fully elucidated. Here, we evaluate multiple longitudinal immunization regimens of mRNA BNT162b2 to assess the effects of a booster dose provided >8 months after the primary immunization series across the murine lifespan, including in aged 21-month-old mice. Boosting dramatically enhances humoral and cell-mediated responses with evidence of Omicron cross-recognition. Furthermore, while younger mice are protected without a booster dose, boosting provides sterilizing immunity against Omicron-induced lung infection in aged 21-month-old mice. Correlational analyses reveal that neutralizing activity against Omicron is strongly associated with protection. Overall, our findings indicate age-dependent vaccine efficacy and demonstrate the potential benefit of mRNA booster immunization to protect vulnerable older populations against SARS-CoV-2 variants. Nature Publishing Group UK 2022-08-06 /pmc/articles/PMC9357006/ /pubmed/35933439 http://dx.doi.org/10.1038/s42003-022-03765-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nanishi, Etsuro
McGrath, Marisa E.
O’Meara, Timothy R.
Barman, Soumik
Yu, Jingyou
Wan, Huahua
Dillen, Carly A.
Menon, Manisha
Seo, Hyuk-Soo
Song, Kijun
Xu, Andrew Z.
Sebastian, Luke
Brook, Byron
Bosco, Anna-Nicole
Borriello, Francesco
Ernst, Robert K.
Barouch, Dan H.
Dhe-Paganon, Sirano
Levy, Ofer
Frieman, Matthew B.
Dowling, David J.
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
title mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
title_full mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
title_fullStr mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
title_full_unstemmed mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
title_short mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
title_sort mrna booster vaccination protects aged mice against the sars-cov-2 omicron variant
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357006/
https://www.ncbi.nlm.nih.gov/pubmed/35933439
http://dx.doi.org/10.1038/s42003-022-03765-3
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