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Structural and dynamic mechanisms of GABA(A) receptor modulators with opposing activities

γ-Aminobutyric acid type A (GABA(A)) receptors are pentameric ligand-gated ion channels abundant in the central nervous system and are prolific drug targets for treating anxiety, sleep disorders and epilepsy. Diverse small molecules exert a spectrum of effects on γ-aminobutyric acid type A (GABA(A))...

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Detalles Bibliográficos
Autores principales:	Zhu, Shaotong, Sridhar, Akshay, Teng, Jinfeng, Howard, Rebecca J., Lindahl, Erik, Hibbs, Ryan E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357065/ https://www.ncbi.nlm.nih.gov/pubmed/35933426 http://dx.doi.org/10.1038/s41467-022-32212-4

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