Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson’s models via regulating autophagy-lysosome pathway

The abnormal accumulation of α-synuclein (α-syn) is a crucial factor for the onset and pathogenesis of Parkinson’s disease (PD), and the autophagy-lysosome pathway (ALP) contributes to α-syn turnover. AMP-activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR) regulate autophagy...

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Detalles Bibliográficos
Autores principales: Xu, Jie, Ao, Yun-Lin, Huang, Chunhui, Song, Xiubao, Zhang, Guiliang, Cui, Wei, Wang, Yuqiang, Zhang, Xiao-Qi, Zhang, Zaijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357076/
https://www.ncbi.nlm.nih.gov/pubmed/35933473
http://dx.doi.org/10.1038/s41531-022-00361-4

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