BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Activated B cell–like diffuse large B-cell lymphomas (ABC-DLBCL) have unfavorable outcomes and chronic activation of CARD11–BCL10–MALT1 (CBM) signal amplification complexes that form due to polymerization of BCL10 subunits, which is affected by recurrent somatic mutations in ABC-DLBCLs. Herein, we s...

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Detalles Bibliográficos
Autores principales: Xia, Min, David, Liron, Teater, Matt, Gutierrez, Johana, Wang, Xiang, Meydan, Cem, Lytle, Andrew, Slack, Graham W., Scott, David W., Morin, Ryan D., Onder, Ozlem, Elenitoba-Johnson, Kojo S.J., Zamponi, Nahuel, Cerchietti, Leandro, Lu, Tianbao, Philippar, Ulrike, Fontan, Lorena, Wu, Hao, Melnick, Ari M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357155/
https://www.ncbi.nlm.nih.gov/pubmed/35658124
http://dx.doi.org/10.1158/2159-8290.CD-21-1566

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