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Differences in H3K4me3 and chromatin accessibility contribute to altered T‐cell receptor signaling in neonatal naïve CD4 T cells

Neonatal CD4(+) T cells have reduced or delayed T‐cell receptor (TCR) signaling responses compared with adult cells, but the mechanisms underlying this are poorly understood. This study tested the hypothesis that human neonatal naïve CD4(+) TCR signaling and activation deficits are related to differ...

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Detalles Bibliográficos
Autores principales:	Bermick, Jennifer R, Issuree, Priya, denDekker, Aaron, Gallagher, Katherine A, Santillan, Donna, Kunkel, Steven, Lukacs, Nicholas, Schaller, Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357221/ https://www.ncbi.nlm.nih.gov/pubmed/35608955 http://dx.doi.org/10.1111/imcb.12561

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