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Differences in lung function between major race/ethnicity groups following hospitalization with COVID-19
BACKGROUND: Ethnic minorities have higher rates of infection, hospitalization, and death from COVID-19 compared to White Americans. RESEARCH QUESTION: Is race/ethnicity an independent predictor of lung dysfunction following hospitalization with COVID-19? STUDY DESIGN: and Methods: Patients hospitali...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357276/ https://www.ncbi.nlm.nih.gov/pubmed/36029696 http://dx.doi.org/10.1016/j.rmed.2022.106939 |
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author | Konkol, Samuel B. Ramani, Chintan Martin, David N. Harnish-Cruz, Carissa K. Mietla, Kelsie M. Sessums, Ryan F. Widere, John C. Kadl, Alexandra |
author_facet | Konkol, Samuel B. Ramani, Chintan Martin, David N. Harnish-Cruz, Carissa K. Mietla, Kelsie M. Sessums, Ryan F. Widere, John C. Kadl, Alexandra |
author_sort | Konkol, Samuel B. |
collection | PubMed |
description | BACKGROUND: Ethnic minorities have higher rates of infection, hospitalization, and death from COVID-19 compared to White Americans. RESEARCH QUESTION: Is race/ethnicity an independent predictor of lung dysfunction following hospitalization with COVID-19? STUDY DESIGN: and Methods: Patients hospitalized at the University of Virginia Medical Center with COVID-19 underwent a questionnaire within 30 days following discharge. Those who had persistent respiratory symptoms were invited to complete spirometry, lung volumes, and diffusion capacity of carbon monoxide. 128 completed pulmonary function testing at 6 months. RESULTS: Impairments in lung function were present in spirometry, lung volumes, and diffusion capacity of carbon monoxide at 6 months. The most prevalent impairments were noted in FVC (24.4%), FEV1 (20.5%), TLC (23.3%), and DLCO (20.8%). When compared between race/ethnicity groups three lung function parameters demonstrated statistically significant difference, including FEV1/FVC (p = 0.021), RV/TLC (p = 0.006) and DLCO % predicted (p = 0.002). The average difference between Hispanic and non-Hispanic Black patients with respect to DLCO % predicted was 13.09 (p = 0.01) and the average difference between non-Hispanic White and non-Hispanic Black patients was 9.46 (p = 0.04). Differences persisted when controlling for age, BMI, smoking status, history of chronic lung disease, ICU admission, treatment with corticosteroids, and socioeconomic status. INTERPRETATION: Long-term impairments in lung function following COVID-19 are common, occurring in roughly 22% of patients and across all three major domains of lung function. Non-Hispanic Black race/ethnicity was associated with a statistically significant lower DLCO % predicted when compared to non-Hispanic White and Hispanic patients. |
format | Online Article Text |
id | pubmed-9357276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93572762022-08-07 Differences in lung function between major race/ethnicity groups following hospitalization with COVID-19 Konkol, Samuel B. Ramani, Chintan Martin, David N. Harnish-Cruz, Carissa K. Mietla, Kelsie M. Sessums, Ryan F. Widere, John C. Kadl, Alexandra Respir Med Original Research BACKGROUND: Ethnic minorities have higher rates of infection, hospitalization, and death from COVID-19 compared to White Americans. RESEARCH QUESTION: Is race/ethnicity an independent predictor of lung dysfunction following hospitalization with COVID-19? STUDY DESIGN: and Methods: Patients hospitalized at the University of Virginia Medical Center with COVID-19 underwent a questionnaire within 30 days following discharge. Those who had persistent respiratory symptoms were invited to complete spirometry, lung volumes, and diffusion capacity of carbon monoxide. 128 completed pulmonary function testing at 6 months. RESULTS: Impairments in lung function were present in spirometry, lung volumes, and diffusion capacity of carbon monoxide at 6 months. The most prevalent impairments were noted in FVC (24.4%), FEV1 (20.5%), TLC (23.3%), and DLCO (20.8%). When compared between race/ethnicity groups three lung function parameters demonstrated statistically significant difference, including FEV1/FVC (p = 0.021), RV/TLC (p = 0.006) and DLCO % predicted (p = 0.002). The average difference between Hispanic and non-Hispanic Black patients with respect to DLCO % predicted was 13.09 (p = 0.01) and the average difference between non-Hispanic White and non-Hispanic Black patients was 9.46 (p = 0.04). Differences persisted when controlling for age, BMI, smoking status, history of chronic lung disease, ICU admission, treatment with corticosteroids, and socioeconomic status. INTERPRETATION: Long-term impairments in lung function following COVID-19 are common, occurring in roughly 22% of patients and across all three major domains of lung function. Non-Hispanic Black race/ethnicity was associated with a statistically significant lower DLCO % predicted when compared to non-Hispanic White and Hispanic patients. Elsevier Ltd. 2022-09 2022-08-07 /pmc/articles/PMC9357276/ /pubmed/36029696 http://dx.doi.org/10.1016/j.rmed.2022.106939 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Research Konkol, Samuel B. Ramani, Chintan Martin, David N. Harnish-Cruz, Carissa K. Mietla, Kelsie M. Sessums, Ryan F. Widere, John C. Kadl, Alexandra Differences in lung function between major race/ethnicity groups following hospitalization with COVID-19 |
title | Differences in lung function between major race/ethnicity groups following hospitalization with COVID-19 |
title_full | Differences in lung function between major race/ethnicity groups following hospitalization with COVID-19 |
title_fullStr | Differences in lung function between major race/ethnicity groups following hospitalization with COVID-19 |
title_full_unstemmed | Differences in lung function between major race/ethnicity groups following hospitalization with COVID-19 |
title_short | Differences in lung function between major race/ethnicity groups following hospitalization with COVID-19 |
title_sort | differences in lung function between major race/ethnicity groups following hospitalization with covid-19 |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357276/ https://www.ncbi.nlm.nih.gov/pubmed/36029696 http://dx.doi.org/10.1016/j.rmed.2022.106939 |
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