Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury

BACKGROUND: Histone deacetylases (HDACs) are believed to exacerbate traumatic brain injury (TBI) based on studies using pan-HDAC inhibitors. However, the HDAC isoform responsible for the detrimental effects and the cell types involved remain unknown, which may hinder the development of specific targ...

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Detalles Bibliográficos
Autores principales: Zhao, Yongfang, Mu, Hongfeng, Huang, Yichen, Li, Sicheng, Wang, Yangfan, Stetler, R. Anne, Bennett, Michael V. L., Dixon, C. Edward, Chen, Jun, Shi, Yejie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357327/
https://www.ncbi.nlm.nih.gov/pubmed/35933343
http://dx.doi.org/10.1186/s12974-022-02563-2

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