Human iPSC-derived cerebral organoids model features of Leigh syndrome and reveal abnormal corticogenesis

Leigh syndrome (LS) is a rare, inherited neurometabolic disorder that presents with bilateral brain lesions caused by defects in the mitochondrial respiratory chain and associated nuclear-encoded proteins. We generated human induced pluripotent stem cells (iPSCs) from three LS patient-derived fibrob...

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Detalles Bibliográficos
Autores principales: Romero-Morales, Alejandra I., Robertson, Gabriella L., Rastogi, Anuj, Rasmussen, Megan L., Temuri, Hoor, McElroy, Gregory Scott, Chakrabarty, Ram Prosad, Hsu, Lawrence, Almonacid, Paula M., Millis, Bryan A., Chandel, Navdeep S., Cartailler, Jean-Philippe, Gama, Vivian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Human Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357378/
https://www.ncbi.nlm.nih.gov/pubmed/35792828
http://dx.doi.org/10.1242/dev.199914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357378/
https://www.ncbi.nlm.nih.gov/pubmed/35792828
http://dx.doi.org/10.1242/dev.199914

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