Cargando…

Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020)

Introduction  Neuromyelitis optica spectrum disorders (NMOSD) would disproportionately affect blacks within mixed populations. However, they are rarely reported in black African. The objective of this work was to report the experience of Togo, a West African country in terms of NMOSD. Methods  This...

Descripción completa

Detalles Bibliográficos
Autores principales: Apetse, Kossivi, Kouassi, Komlan, Anayo, Nyinèvi Komla, Waklatsi, Kokouvi Panabalo, Guinhouya, Mensah Kokou, Agba, Léhleng, Kumako, Vinyo Kodzo, Kombate, Damelan, Assogba, Komi, Belo, Mofou, Balogou, Agnon Koffi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357491/
https://www.ncbi.nlm.nih.gov/pubmed/35946029
http://dx.doi.org/10.1055/s-0042-1750081
_version_ 1784763720694497280
author Apetse, Kossivi
Kouassi, Komlan
Anayo, Nyinèvi Komla
Waklatsi, Kokouvi Panabalo
Guinhouya, Mensah Kokou
Agba, Léhleng
Kumako, Vinyo Kodzo
Kombate, Damelan
Assogba, Komi
Belo, Mofou
Balogou, Agnon Koffi
author_facet Apetse, Kossivi
Kouassi, Komlan
Anayo, Nyinèvi Komla
Waklatsi, Kokouvi Panabalo
Guinhouya, Mensah Kokou
Agba, Léhleng
Kumako, Vinyo Kodzo
Kombate, Damelan
Assogba, Komi
Belo, Mofou
Balogou, Agnon Koffi
author_sort Apetse, Kossivi
collection PubMed
description Introduction  Neuromyelitis optica spectrum disorders (NMOSD) would disproportionately affect blacks within mixed populations. However, they are rarely reported in black African. The objective of this work was to report the experience of Togo, a West African country in terms of NMOSD. Methods  This is a series of six cases diagnosed between 2015 and 2020 in the only three neurology departments in Togo. The diagnosis of NMOSD was made according to the criteria of the International Panel for NMO Diagnosis (2015) and the patients had a minimum clinical follow-up of 6 months after the diagnosis. The search for anti-aquaporin 4 (AQP4) antibodies was performed by immunofluorescence on transfected cells. Results  The mean age was 25.33 years and the sex ratio female/male was 5/1. The average time between the first attack and the diagnosis was 122.83 days. Clinically, there was isolated medullary involvement (2/6), simultaneous opticomedullary involvement (3/6), and area postrema syndrome (1/6). Five patients were anti-AQP4 positive. All six patients had extensive longitudinal myelitis. At 6 months of follow-up, there was one case of death and one case of blindness. Conclusion  The rarity of NMOSD cases in Togo could be linked to an underestimation. To better characterize the NMOSDs of the black African population, multicenter and multidisciplinary studies are necessary.
format Online
Article
Text
id pubmed-9357491
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
record_format MEDLINE/PubMed
spelling pubmed-93574912022-08-08 Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020) Apetse, Kossivi Kouassi, Komlan Anayo, Nyinèvi Komla Waklatsi, Kokouvi Panabalo Guinhouya, Mensah Kokou Agba, Léhleng Kumako, Vinyo Kodzo Kombate, Damelan Assogba, Komi Belo, Mofou Balogou, Agnon Koffi J Neurosci Rural Pract Introduction  Neuromyelitis optica spectrum disorders (NMOSD) would disproportionately affect blacks within mixed populations. However, they are rarely reported in black African. The objective of this work was to report the experience of Togo, a West African country in terms of NMOSD. Methods  This is a series of six cases diagnosed between 2015 and 2020 in the only three neurology departments in Togo. The diagnosis of NMOSD was made according to the criteria of the International Panel for NMO Diagnosis (2015) and the patients had a minimum clinical follow-up of 6 months after the diagnosis. The search for anti-aquaporin 4 (AQP4) antibodies was performed by immunofluorescence on transfected cells. Results  The mean age was 25.33 years and the sex ratio female/male was 5/1. The average time between the first attack and the diagnosis was 122.83 days. Clinically, there was isolated medullary involvement (2/6), simultaneous opticomedullary involvement (3/6), and area postrema syndrome (1/6). Five patients were anti-AQP4 positive. All six patients had extensive longitudinal myelitis. At 6 months of follow-up, there was one case of death and one case of blindness. Conclusion  The rarity of NMOSD cases in Togo could be linked to an underestimation. To better characterize the NMOSDs of the black African population, multicenter and multidisciplinary studies are necessary. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-07-11 /pmc/articles/PMC9357491/ /pubmed/35946029 http://dx.doi.org/10.1055/s-0042-1750081 Text en Association for Helping Neurosurgical Sick People. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Apetse, Kossivi
Kouassi, Komlan
Anayo, Nyinèvi Komla
Waklatsi, Kokouvi Panabalo
Guinhouya, Mensah Kokou
Agba, Léhleng
Kumako, Vinyo Kodzo
Kombate, Damelan
Assogba, Komi
Belo, Mofou
Balogou, Agnon Koffi
Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020)
title Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020)
title_full Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020)
title_fullStr Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020)
title_full_unstemmed Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020)
title_short Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020)
title_sort neuromyelitis optica spectrum disorders in black african: experience of togo (2015–2020)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357491/
https://www.ncbi.nlm.nih.gov/pubmed/35946029
http://dx.doi.org/10.1055/s-0042-1750081
work_keys_str_mv AT apetsekossivi neuromyelitisopticaspectrumdisordersinblackafricanexperienceoftogo20152020
AT kouassikomlan neuromyelitisopticaspectrumdisordersinblackafricanexperienceoftogo20152020
AT anayonyinevikomla neuromyelitisopticaspectrumdisordersinblackafricanexperienceoftogo20152020
AT waklatsikokouvipanabalo neuromyelitisopticaspectrumdisordersinblackafricanexperienceoftogo20152020
AT guinhouyamensahkokou neuromyelitisopticaspectrumdisordersinblackafricanexperienceoftogo20152020
AT agbalehleng neuromyelitisopticaspectrumdisordersinblackafricanexperienceoftogo20152020
AT kumakovinyokodzo neuromyelitisopticaspectrumdisordersinblackafricanexperienceoftogo20152020
AT kombatedamelan neuromyelitisopticaspectrumdisordersinblackafricanexperienceoftogo20152020
AT assogbakomi neuromyelitisopticaspectrumdisordersinblackafricanexperienceoftogo20152020
AT belomofou neuromyelitisopticaspectrumdisordersinblackafricanexperienceoftogo20152020
AT balogouagnonkoffi neuromyelitisopticaspectrumdisordersinblackafricanexperienceoftogo20152020