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Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020)
Introduction Neuromyelitis optica spectrum disorders (NMOSD) would disproportionately affect blacks within mixed populations. However, they are rarely reported in black African. The objective of this work was to report the experience of Togo, a West African country in terms of NMOSD. Methods This...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357491/ https://www.ncbi.nlm.nih.gov/pubmed/35946029 http://dx.doi.org/10.1055/s-0042-1750081 |
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author | Apetse, Kossivi Kouassi, Komlan Anayo, Nyinèvi Komla Waklatsi, Kokouvi Panabalo Guinhouya, Mensah Kokou Agba, Léhleng Kumako, Vinyo Kodzo Kombate, Damelan Assogba, Komi Belo, Mofou Balogou, Agnon Koffi |
author_facet | Apetse, Kossivi Kouassi, Komlan Anayo, Nyinèvi Komla Waklatsi, Kokouvi Panabalo Guinhouya, Mensah Kokou Agba, Léhleng Kumako, Vinyo Kodzo Kombate, Damelan Assogba, Komi Belo, Mofou Balogou, Agnon Koffi |
author_sort | Apetse, Kossivi |
collection | PubMed |
description | Introduction Neuromyelitis optica spectrum disorders (NMOSD) would disproportionately affect blacks within mixed populations. However, they are rarely reported in black African. The objective of this work was to report the experience of Togo, a West African country in terms of NMOSD. Methods This is a series of six cases diagnosed between 2015 and 2020 in the only three neurology departments in Togo. The diagnosis of NMOSD was made according to the criteria of the International Panel for NMO Diagnosis (2015) and the patients had a minimum clinical follow-up of 6 months after the diagnosis. The search for anti-aquaporin 4 (AQP4) antibodies was performed by immunofluorescence on transfected cells. Results The mean age was 25.33 years and the sex ratio female/male was 5/1. The average time between the first attack and the diagnosis was 122.83 days. Clinically, there was isolated medullary involvement (2/6), simultaneous opticomedullary involvement (3/6), and area postrema syndrome (1/6). Five patients were anti-AQP4 positive. All six patients had extensive longitudinal myelitis. At 6 months of follow-up, there was one case of death and one case of blindness. Conclusion The rarity of NMOSD cases in Togo could be linked to an underestimation. To better characterize the NMOSDs of the black African population, multicenter and multidisciplinary studies are necessary. |
format | Online Article Text |
id | pubmed-9357491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93574912022-08-08 Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020) Apetse, Kossivi Kouassi, Komlan Anayo, Nyinèvi Komla Waklatsi, Kokouvi Panabalo Guinhouya, Mensah Kokou Agba, Léhleng Kumako, Vinyo Kodzo Kombate, Damelan Assogba, Komi Belo, Mofou Balogou, Agnon Koffi J Neurosci Rural Pract Introduction Neuromyelitis optica spectrum disorders (NMOSD) would disproportionately affect blacks within mixed populations. However, they are rarely reported in black African. The objective of this work was to report the experience of Togo, a West African country in terms of NMOSD. Methods This is a series of six cases diagnosed between 2015 and 2020 in the only three neurology departments in Togo. The diagnosis of NMOSD was made according to the criteria of the International Panel for NMO Diagnosis (2015) and the patients had a minimum clinical follow-up of 6 months after the diagnosis. The search for anti-aquaporin 4 (AQP4) antibodies was performed by immunofluorescence on transfected cells. Results The mean age was 25.33 years and the sex ratio female/male was 5/1. The average time between the first attack and the diagnosis was 122.83 days. Clinically, there was isolated medullary involvement (2/6), simultaneous opticomedullary involvement (3/6), and area postrema syndrome (1/6). Five patients were anti-AQP4 positive. All six patients had extensive longitudinal myelitis. At 6 months of follow-up, there was one case of death and one case of blindness. Conclusion The rarity of NMOSD cases in Togo could be linked to an underestimation. To better characterize the NMOSDs of the black African population, multicenter and multidisciplinary studies are necessary. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-07-11 /pmc/articles/PMC9357491/ /pubmed/35946029 http://dx.doi.org/10.1055/s-0042-1750081 Text en Association for Helping Neurosurgical Sick People. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Apetse, Kossivi Kouassi, Komlan Anayo, Nyinèvi Komla Waklatsi, Kokouvi Panabalo Guinhouya, Mensah Kokou Agba, Léhleng Kumako, Vinyo Kodzo Kombate, Damelan Assogba, Komi Belo, Mofou Balogou, Agnon Koffi Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020) |
title | Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020) |
title_full | Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020) |
title_fullStr | Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020) |
title_full_unstemmed | Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020) |
title_short | Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020) |
title_sort | neuromyelitis optica spectrum disorders in black african: experience of togo (2015–2020) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357491/ https://www.ncbi.nlm.nih.gov/pubmed/35946029 http://dx.doi.org/10.1055/s-0042-1750081 |
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