Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage

Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion of packed red blood cells containing a high amount of myeloid...

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Detalles Bibliográficos
Autores principales: Vourc’h, Mickael, Roquilly, Antoine, Foucher, Adrien, Retiere, Christelle, Feuillet, Fanny, Devi, Sapna, McWilliam, Hamish E.G., Braudeau, Cecile, Bourreille, Geraldine, Hachani, Abderrahman, O’Kane, Dermot, Mueller, Scott N., Ischia, Joseph, Roussel, Jean-Christian, Rigal, Jean-Christophe, Josien, Regis, Rozec, Bertrand, Villadangos, Jose A., Asehnoune, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357562/
https://www.ncbi.nlm.nih.gov/pubmed/35958696
http://dx.doi.org/10.1016/j.jacbts.2022.02.019
Descripción
Sumario:Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion of packed red blood cells containing a high amount of myeloid-related protein 14 (MRP_14) could increase the incidence of AKI after cardiac surgery. In a mouse model, MRP_14 increased the influx of neutrophils in the kidney after ischemia-reperfusion and their ability to damage tubular cells. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration.

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