Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage

Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion of packed red blood cells containing a high amount of myeloid...

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Autores principales: Vourc’h, Mickael, Roquilly, Antoine, Foucher, Adrien, Retiere, Christelle, Feuillet, Fanny, Devi, Sapna, McWilliam, Hamish E.G., Braudeau, Cecile, Bourreille, Geraldine, Hachani, Abderrahman, O’Kane, Dermot, Mueller, Scott N., Ischia, Joseph, Roussel, Jean-Christian, Rigal, Jean-Christophe, Josien, Regis, Rozec, Bertrand, Villadangos, Jose A., Asehnoune, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357562/
https://www.ncbi.nlm.nih.gov/pubmed/35958696
http://dx.doi.org/10.1016/j.jacbts.2022.02.019
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author Vourc’h, Mickael
Roquilly, Antoine
Foucher, Adrien
Retiere, Christelle
Feuillet, Fanny
Devi, Sapna
McWilliam, Hamish E.G.
Braudeau, Cecile
Bourreille, Geraldine
Hachani, Abderrahman
O’Kane, Dermot
Mueller, Scott N.
Ischia, Joseph
Roussel, Jean-Christian
Rigal, Jean-Christophe
Josien, Regis
Rozec, Bertrand
Villadangos, Jose A.
Asehnoune, Karim
author_facet Vourc’h, Mickael
Roquilly, Antoine
Foucher, Adrien
Retiere, Christelle
Feuillet, Fanny
Devi, Sapna
McWilliam, Hamish E.G.
Braudeau, Cecile
Bourreille, Geraldine
Hachani, Abderrahman
O’Kane, Dermot
Mueller, Scott N.
Ischia, Joseph
Roussel, Jean-Christian
Rigal, Jean-Christophe
Josien, Regis
Rozec, Bertrand
Villadangos, Jose A.
Asehnoune, Karim
author_sort Vourc’h, Mickael
collection PubMed
description Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion of packed red blood cells containing a high amount of myeloid-related protein 14 (MRP_14) could increase the incidence of AKI after cardiac surgery. In a mouse model, MRP_14 increased the influx of neutrophils in the kidney after ischemia-reperfusion and their ability to damage tubular cells. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration.
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spelling pubmed-93575622022-08-10 Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage Vourc’h, Mickael Roquilly, Antoine Foucher, Adrien Retiere, Christelle Feuillet, Fanny Devi, Sapna McWilliam, Hamish E.G. Braudeau, Cecile Bourreille, Geraldine Hachani, Abderrahman O’Kane, Dermot Mueller, Scott N. Ischia, Joseph Roussel, Jean-Christian Rigal, Jean-Christophe Josien, Regis Rozec, Bertrand Villadangos, Jose A. Asehnoune, Karim JACC Basic Transl Sci Original Research - Clinical Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion of packed red blood cells containing a high amount of myeloid-related protein 14 (MRP_14) could increase the incidence of AKI after cardiac surgery. In a mouse model, MRP_14 increased the influx of neutrophils in the kidney after ischemia-reperfusion and their ability to damage tubular cells. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration. Elsevier 2022-06-01 /pmc/articles/PMC9357562/ /pubmed/35958696 http://dx.doi.org/10.1016/j.jacbts.2022.02.019 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research - Clinical
Vourc’h, Mickael
Roquilly, Antoine
Foucher, Adrien
Retiere, Christelle
Feuillet, Fanny
Devi, Sapna
McWilliam, Hamish E.G.
Braudeau, Cecile
Bourreille, Geraldine
Hachani, Abderrahman
O’Kane, Dermot
Mueller, Scott N.
Ischia, Joseph
Roussel, Jean-Christian
Rigal, Jean-Christophe
Josien, Regis
Rozec, Bertrand
Villadangos, Jose A.
Asehnoune, Karim
Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage
title Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage
title_full Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage
title_fullStr Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage
title_full_unstemmed Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage
title_short Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage
title_sort transfusion-related renal dysfunction after cardiac surgery: the role of myeloid-related protein_14 in neutrophil-mediated tubular damage
topic Original Research - Clinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357562/
https://www.ncbi.nlm.nih.gov/pubmed/35958696
http://dx.doi.org/10.1016/j.jacbts.2022.02.019
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