PTP1B Inhibition Improves Mitochondrial Dynamics to Alleviate Calcific Aortic Valve Disease Via Regulating OPA1 Homeostasis

There are currently no pharmacological therapies for calcific aortic valve disease (CAVD). Here, we evaluated the role of protein tyrosine phosphatase 1B (PTP1B) inhibition in CAVD. Up-regulation of PTP1B was critically involved in calcified human aortic valve, and PTP1B inhibition had beneficial ef...

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Detalles Bibliográficos
Autores principales: Liu, Feng, Chen, Jinyong, Hu, Wangxing, Gao, Chenyang, Zeng, Zhiru, Cheng, Si, Yu, Kaixiang, Qian, Yi, Xu, Dilin, Zhu, Gangjie, Zhao, Jing, Liu, Xianbao, Wang, Jian'an
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357565/
https://www.ncbi.nlm.nih.gov/pubmed/35958694
http://dx.doi.org/10.1016/j.jacbts.2022.03.002

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