Cargando…
Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis
Both diabetes types, types 1 and 2, are associated with cognitive impairments. Each period of life is concerned, and this is an increasing public health problem. Animal models have been developed to investigate the biological actors involved in such impairments. Many levels of the brain function (st...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357829/ https://www.ncbi.nlm.nih.gov/pubmed/35958117 http://dx.doi.org/10.1016/j.metop.2022.100202 |
_version_ | 1784763798059483136 |
---|---|
author | Marissal-Arvy, Nathalie Moisan, Marie-Pierre |
author_facet | Marissal-Arvy, Nathalie Moisan, Marie-Pierre |
author_sort | Marissal-Arvy, Nathalie |
collection | PubMed |
description | Both diabetes types, types 1 and 2, are associated with cognitive impairments. Each period of life is concerned, and this is an increasing public health problem. Animal models have been developed to investigate the biological actors involved in such impairments. Many levels of the brain function (structure, volume, neurogenesis, neurotransmission, behavior) are involved. In this review, we detailed the part potentially played by the Hypothalamic-Pituitary Adrenal axis in these dysfunctions. Notably, regulating glucocorticoid levels, their receptors and their bioavailability appear to be relevant for future research studies, and treatment development. |
format | Online Article Text |
id | pubmed-9357829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-93578292022-08-10 Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis Marissal-Arvy, Nathalie Moisan, Marie-Pierre Metabol Open Review Both diabetes types, types 1 and 2, are associated with cognitive impairments. Each period of life is concerned, and this is an increasing public health problem. Animal models have been developed to investigate the biological actors involved in such impairments. Many levels of the brain function (structure, volume, neurogenesis, neurotransmission, behavior) are involved. In this review, we detailed the part potentially played by the Hypothalamic-Pituitary Adrenal axis in these dysfunctions. Notably, regulating glucocorticoid levels, their receptors and their bioavailability appear to be relevant for future research studies, and treatment development. Elsevier 2022-07-31 /pmc/articles/PMC9357829/ /pubmed/35958117 http://dx.doi.org/10.1016/j.metop.2022.100202 Text en © 2022 Institut National de la Recherche pour l'Agriculture, l'alimentation et l'environnement https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Marissal-Arvy, Nathalie Moisan, Marie-Pierre Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis |
title | Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis |
title_full | Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis |
title_fullStr | Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis |
title_full_unstemmed | Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis |
title_short | Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis |
title_sort | diabetes and associated cognitive disorders: role of the hypothalamic-pituitary adrenal axis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357829/ https://www.ncbi.nlm.nih.gov/pubmed/35958117 http://dx.doi.org/10.1016/j.metop.2022.100202 |
work_keys_str_mv | AT marissalarvynathalie diabetesandassociatedcognitivedisordersroleofthehypothalamicpituitaryadrenalaxis AT moisanmariepierre diabetesandassociatedcognitivedisordersroleofthehypothalamicpituitaryadrenalaxis |