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Pretransplant characteristics of kidney transplant recipients that predict posttransplant outcome

Better characterization of the potential kidney transplant recipient using novel biomarkers, for example, pretransplant plasma endotrophin, will lead to improved outcome after transplantation. This mini-review will focus on current knowledge about pretransplant recipients’ characteristics, biomarker...

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Autores principales: Tepel, Martin, Nagarajah, Subagini, Saleh, Qais, Thaunat, Olivier, Bakker, Stephan J. L., van den Born, Jacob, Karsdal, Morten A., Genovese, Federica, Rasmussen, Daniel G. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357871/
https://www.ncbi.nlm.nih.gov/pubmed/35958571
http://dx.doi.org/10.3389/fimmu.2022.945288
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author Tepel, Martin
Nagarajah, Subagini
Saleh, Qais
Thaunat, Olivier
Bakker, Stephan J. L.
van den Born, Jacob
Karsdal, Morten A.
Genovese, Federica
Rasmussen, Daniel G. K.
author_facet Tepel, Martin
Nagarajah, Subagini
Saleh, Qais
Thaunat, Olivier
Bakker, Stephan J. L.
van den Born, Jacob
Karsdal, Morten A.
Genovese, Federica
Rasmussen, Daniel G. K.
author_sort Tepel, Martin
collection PubMed
description Better characterization of the potential kidney transplant recipient using novel biomarkers, for example, pretransplant plasma endotrophin, will lead to improved outcome after transplantation. This mini-review will focus on current knowledge about pretransplant recipients’ characteristics, biomarkers, and immunology. Clinical characteristics of recipients including age, obesity, blood pressure, comorbidities, and estimated survival scores have been introduced for prediction of recipient and allograft survival. The pretransplant immunologic risk assessment include histocompatibility leukocyte antigens (HLAs), anti-HLA donor-specific antibodies, HLA-DQ mismatch, and non-HLA antibodies. Recently, there has been the hope that pretransplant determination of markers can further improve the prediction of posttransplant complications, both short-term and long-term outcomes including rejections, allograft loss, and mortality. Higher pretransplant plasma endotrophin levels were independently associated with posttransplant acute allograft injury in three prospective European cohorts. Elevated numbers of non-synonymous single-nucleotide polymorphism mismatch have been associated with increased allograft loss in a multivariable analysis. It is concluded that there is a need for integration of clinical characteristics and novel molecular and immunological markers to improve future transplant medicine to reach better diagnostic decisions tailored to the individual patient.
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spelling pubmed-93578712022-08-10 Pretransplant characteristics of kidney transplant recipients that predict posttransplant outcome Tepel, Martin Nagarajah, Subagini Saleh, Qais Thaunat, Olivier Bakker, Stephan J. L. van den Born, Jacob Karsdal, Morten A. Genovese, Federica Rasmussen, Daniel G. K. Front Immunol Immunology Better characterization of the potential kidney transplant recipient using novel biomarkers, for example, pretransplant plasma endotrophin, will lead to improved outcome after transplantation. This mini-review will focus on current knowledge about pretransplant recipients’ characteristics, biomarkers, and immunology. Clinical characteristics of recipients including age, obesity, blood pressure, comorbidities, and estimated survival scores have been introduced for prediction of recipient and allograft survival. The pretransplant immunologic risk assessment include histocompatibility leukocyte antigens (HLAs), anti-HLA donor-specific antibodies, HLA-DQ mismatch, and non-HLA antibodies. Recently, there has been the hope that pretransplant determination of markers can further improve the prediction of posttransplant complications, both short-term and long-term outcomes including rejections, allograft loss, and mortality. Higher pretransplant plasma endotrophin levels were independently associated with posttransplant acute allograft injury in three prospective European cohorts. Elevated numbers of non-synonymous single-nucleotide polymorphism mismatch have been associated with increased allograft loss in a multivariable analysis. It is concluded that there is a need for integration of clinical characteristics and novel molecular and immunological markers to improve future transplant medicine to reach better diagnostic decisions tailored to the individual patient. Frontiers Media S.A. 2022-07-25 /pmc/articles/PMC9357871/ /pubmed/35958571 http://dx.doi.org/10.3389/fimmu.2022.945288 Text en Copyright © 2022 Tepel, Nagarajah, Saleh, Thaunat, Bakker, van den Born, Karsdal, Genovese and Rasmussen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tepel, Martin
Nagarajah, Subagini
Saleh, Qais
Thaunat, Olivier
Bakker, Stephan J. L.
van den Born, Jacob
Karsdal, Morten A.
Genovese, Federica
Rasmussen, Daniel G. K.
Pretransplant characteristics of kidney transplant recipients that predict posttransplant outcome
title Pretransplant characteristics of kidney transplant recipients that predict posttransplant outcome
title_full Pretransplant characteristics of kidney transplant recipients that predict posttransplant outcome
title_fullStr Pretransplant characteristics of kidney transplant recipients that predict posttransplant outcome
title_full_unstemmed Pretransplant characteristics of kidney transplant recipients that predict posttransplant outcome
title_short Pretransplant characteristics of kidney transplant recipients that predict posttransplant outcome
title_sort pretransplant characteristics of kidney transplant recipients that predict posttransplant outcome
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357871/
https://www.ncbi.nlm.nih.gov/pubmed/35958571
http://dx.doi.org/10.3389/fimmu.2022.945288
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